Proteins Associated with Persistent Apical Periodontitis: A Scoping Review.

Q3 Dentistry

Iranian Endodontic Journal Pub Date : 2024-01-01 DOI:10.22037/iej.v19i4.45935

Weslay Rodrigues da Silva, Ana Paula Veras Sobral, Kaline Romeiro, Cleiton Rone Dos Santos Lima, Marina da Cunha Isaltino, Christianne Tavares Velozo Telles, Diana Santana de Albuquerque

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引用次数: 0

Abstract

This scoping review aimed to assess immunohistochemical markers associated with the physiopathogenesis of Persistent Apical Periodontitis. The protocol was adapted from the Joanna Briggs Institute Reviewer's Manual (2017) and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for Scoping Reviews. A total of 239 articles were considered potentially eligible, and their full texts read by two reviewers. Six articles were included. The included articles were published between 1999 and 2017. A total of 12 biomarkers were identified, forkhead box P3, cluster of differentiation (CD)3, CD8, CD450, CD68, transforming growth factor alpha, transforming growth factor-beta1, matrix metalloproteinase-9, receptor activator of nuclear factor kappa beta ligand, osteoprotegerin, CD90 and sex-determining region Y-box 2; categorized according to their applicability. Among the biomarkers identified, receptor activator of nuclear factor kappa beta ligand and osteoprotegerinare were related to bone remodeling in apical periodontitis and may also be associated with persistent apical periodontitis.

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与持久性根尖牙周炎有关的蛋白质：范围综述。

本范围界定综述旨在评估与持久性根尖周炎生理发病机制相关的免疫组化标记物。研究方案改编自乔安娜-布里格斯研究所的《审稿人手册》（2017年），并根据《系统综述和Meta分析首选报告项目》的范围界定综述指南进行报告。共有 239 篇文章被认为可能符合条件，并由两名审稿人阅读了全文。六篇文章被纳入其中。纳入的文章发表于 1999 年至 2017 年之间。共确定了12种生物标记物，包括叉头盒P3、分化簇（CD）3、CD8、CD450、CD68、转化生长因子α、转化生长因子-β1、基质金属蛋白酶-9、核因子卡巴受体激活剂β配体、骨保护素、CD90和性别决定区Y-box 2；并根据其适用性进行了分类。在确定的生物标志物中，核因子卡巴β配体受体激活剂和骨保护gerin与根尖牙周炎的骨重塑有关，也可能与持续性根尖牙周炎有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Endodontic Journal Dentistry-Dentistry (all)

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： The Iranian Endodontic Journal (IEJ) is an international peer-reviewed biomedical publication, the aim of which is to provide a scientific medium of communication for researchers throughout the globe. IEJ aims to publish the highest quality articles, both clinical and scientific, on all aspects of Endodontics. The journal is an official Journal of the Iranian Center for Endodontic Research (ICER) and the Iranian Association of Endodontists (IAE). The Journal welcomes articles related to the scientific or applied aspects of endodontics e.g. original researches, systematic reviews, meta-analyses, review articles, clinical trials, case series/reports, hypotheses, letters to the editor, etc. From the beginning (i.e. since 2006), the IEJ was the first open access endodontic journal in the world, which gave readers free and instant access to published articles and enabling them faster discovery of the latest endodontic research.