Inflammation index in failure of delay functional independence after successful recanalization.

IF 1.7 4区医学 Q4 NEUROSCIENCES

International Journal of Neuroscience Pub Date : 2024-10-30 DOI:10.1080/00207454.2024.2414280

Mengke Zhang, Wenbo Zhao, Chuanjie Wu, Jiali Xu, Wenting Guo, Changhong Ren, Sijie Li, Xunming Ji

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引用次数: 0

Abstract

Background: Failure of delayed neurological improvement (fDNI) following successful recanalization is a prevalent clinical phenomenon in patients who have experienced acute ischemic stroke (AIS). An investigation into the potential link between markers of systemic inflammation such as platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index known as SII, and the occurrence of fDNI in patients received successful reperfusion was conducted.

Methods: The study included patients diagnosed with AIS who underwent thrombectomy and experienced fDNI, as observed in a prospective study conducted from January 2017 to April 2020. In order to identify predictors of fDNI, we performed multivariable logistic regression and receiver operating characteristic (ROC) curve.

Results: Eighty-four patients (23.86%) without early neurological improvement (ENI) experienced DNI, and 268 (76.14%) patients did not show DNI. After adjustment for potential confounders, NLR (adjust OR, 2.131; 95%CI, 1.066-4.259; p = 0.032) and SII (adjust OR, 1.065; 95%CI, 1.001-1.132, p = 0.045) exhibited independent reationship with fDNI independently in multivariate analysis. The areas under AUC of multivariable NLR and SII mode were 0.862 and 0.861, respectively.

Conclusions: The immune-inflammatory biomarkers, including NLR and SII, exhibited associations with DNI in patients without ENI. Further investigations are warranted to elucidate the underlying mechanisms.

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成功再通后未能延迟功能独立的炎症指数。

背景：在急性缺血性卒中（AIS）患者中，再通血管成功后延迟神经功能改善（fDNI）失败是一种普遍的临床现象。本研究调查了全身炎症指标（如血小板与淋巴细胞比值（PLR）、中性粒细胞与淋巴细胞比值（NLR）、单核细胞与淋巴细胞比值（MLR）、全身免疫炎症指数（SII））与再灌注成功患者发生延迟神经功能改善之间的潜在联系：研究纳入了2017年1月至2020年4月进行的前瞻性研究中观察到的接受血栓切除术并出现fDNI的AIS患者。为了确定fDNI的预测因素，我们进行了多变量逻辑回归和接收器操作特征曲线（ROC）分析：84例（23.86%）无早期神经功能改善（ENI）的患者出现了DNI，268例（76.14%）患者未出现DNI。调整潜在混杂因素后，NLR（调整 OR，2.131；95%CI，1.066-4.259；P = 0.032）和 SII（调整 OR，1.065；95%CI，1.001-1.132；P = 0.045）在多变量分析中独立显示出与 fDNI 的关系。多变量 NLR 和 SII 模式的 AUC 下面积分别为 0.862 和 0.861：包括 NLR 和 SII 在内的免疫炎症生物标志物与无 ENI 患者的 DNI 存在关联。需要进一步研究以阐明其潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Neuroscience 医学-神经科学

CiteScore

5.10

自引率

0.00%

发文量

132

审稿时长

2 months

期刊介绍： The International Journal of Neuroscience publishes original research articles, reviews, brief scientific reports, case studies, letters to the editor and book reviews concerned with problems of the nervous system and related clinical studies, epidemiology, neuropathology, medical and surgical treatment options and outcomes, neuropsychology and other topics related to the research and care of persons with neurologic disorders. The focus of the journal is clinical and transitional research. Topics covered include but are not limited to: ALS, ataxia, autism, brain tumors, child neurology, demyelinating diseases, epilepsy, genetics, headache, lysosomal storage disease, mitochondrial dysfunction, movement disorders, multiple sclerosis, myopathy, neurodegenerative diseases, neuromuscular disorders, neuropharmacology, neuropsychiatry, neuropsychology, pain, sleep disorders, stroke, and other areas related to the neurosciences.