Association of leukocyte telomere length and the risk of disease severity and metabolic comorbidities in Arab patients with psoriasis.

IF 1.7 4区生物学 Q4 CELL BIOLOGY

Cytogenetic and Genome Research Pub Date : 2024-10-28 DOI:10.1159/000542323

Materah Salem Alwehaidah, Moiz Bakhiet

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引用次数: 0

Abstract

Introduction: Several studies have related shortened leukocyte telomere length (LTL) with age-related diseases and worse prognosis. Telomere length attrition has recently been associated with inflammatory diseases, including psoriasis. However, no study has demonstrated an association between LTL and the risk of disease severity and metabolic comorbidities in Arab patients with psoriasis (Ps).

Methods: 68 Ps and 42 normal controls (NC) were included. LTL and oxidative damage were determined by quantitative (q) PCR. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using logistic regression. Statistical differences between the groups were determined using 2 and t-tests.

Results: Patients with psoriasis had significantly shorter LTL (P= 0.032) and higher oxidative damage (P= 0.015) than those without psoriasis. Patients with moderate-to-severe index (P= 0.03) and metabolic comorbidity showed significantly shorter LTL (P= 0.003) compared to patients with mild index and without metabolic comorbidity, respectively. Patients with short LTL (≤ 0.9) were correlated with higher risk of moderate-to-severe conditions (OR= 6.98, 95% CI= 2.3-20.8, P= 0.001) and metabolic comorbidities (OR= 2.89, 95% CI= 1.02- 8.2, P= 0.04).

Conclusion: LTL shortening may be a consequence of increased oxidative damage, and is related to the risk of severe psoriasis and metabolic comorbidities. Therefore, LTL may be a good candidate biomarker for predicting the risk of poor prognosis in patients with psoriasis.

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阿拉伯银屑病患者的白细胞端粒长度与疾病严重程度和代谢合并症风险的关系。

导言多项研究表明，白细胞端粒长度（LTL）缩短与年龄相关疾病和预后不良有关。最近，端粒长度缩短与包括银屑病在内的炎症性疾病有关。方法：纳入 68 名银屑病患者和 42 名正常对照组（NC）。方法：纳入 68 名银屑病患者和 42 名正常对照组（NC）。采用逻辑回归法计算出患病率（OR）和 95% 的置信区间（CI）。使用 2 和 t 检验确定组间统计差异：银屑病患者的LTL明显短于无银屑病患者（P= 0.032），氧化损伤明显高于无银屑病患者（P= 0.015）。与轻度银屑病患者和无代谢并发症的患者相比，中重度银屑病患者（P= 0.03）和有代谢并发症的患者的LTL明显较短（P= 0.003）。LTL较短（≤ 0.9）的患者患中重度疾病（OR= 6.98，95% CI=2.3-20.8，P= 0.001）和代谢合并症（OR= 2.89，95% CI=1.02-8.2，P= 0.04）的风险较高：LTL缩短可能是氧化损伤增加的结果，与严重银屑病和代谢合并症的风险有关。因此，LTL可能是预测银屑病患者不良预后风险的良好候选生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytogenetic and Genome Research 生物-细胞生物学

CiteScore

3.10

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： During the last decades, ''Cytogenetic and Genome Research'' has been the leading forum for original reports and reviews in human and animal cytogenetics, including molecular, clinical and comparative cytogenetics. In recent years, most of its papers have centered on genome research, including gene cloning and sequencing, gene mapping, gene regulation and expression, cancer genetics, comparative genetics, gene linkage and related areas. The journal also publishes key papers on chromosome aberrations in somatic, meiotic and malignant cells. Its scope has expanded to include studies on invertebrate and plant cytogenetics and genomics. Also featured are the vast majority of the reports of the International Workshops on Human Chromosome Mapping, the reports of international human and animal chromosome nomenclature committees, and proceedings of the American and European cytogenetic conferences and other events. In addition to regular issues, the journal has been publishing since 2002 a series of topical issues on a broad variety of themes from cytogenetic and genome research.