Outbreak of contact allergy to dicyclohexylcarbodiimide in a biotechnology laboratory.

IF 4.8 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2024-10-28 DOI:10.1111/cod.14715

Linas Griguola, Kestutis Cerniauskas, Laura Malinauskiene, Kotryna Linauskiene, Justina Rudyte, Anzelika Chomiciene

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引用次数: 0

Abstract

Background: Dicyclohexylcarbodiimide (DCC) is known to cause occupational allergic contact dermatitis in biotechnology laboratory workers.

Objectives: This study aimed to assess the prevalence of DCC sensitization among workers of one biosynthesis laboratory and to determine the optimal DCC concentration for patch testing.

Materials and methods: 23 laboratory workers frequently exposed to DCC of whom 21 suffered from dermatitis and 11 controls were enrolled into the study. All participants underwent skin patch testing with different concentrations of DCC and other substances used in the work environment. Statistical analysis was conducted to compare results between active and control groups.

Results: Of the 23 workers tested, 56.5% showed positive reactions to DCC. All of them had dermatitis. Morpholine also elicited positive reactions in 26.1% of workers who were all sensitized to DCC. Dimethylformamide and chloroform yielded negative results.

Conclusion: Dicyclohexylcarbodiimide was a major cause of contact dermatitis in the active group indicating an outbreak of contact allergy to DCC in the company necessitating preventive measures. Both DCC 0.1% ac. and DCC 0.05% pet. should both be used for patch testing.

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生物技术实验室爆发二环己基碳二亚胺接触过敏事件。

背景：二环己基碳二亚胺（DCC众所周知，二环己基碳二亚胺（DCC）会导致生物技术实验室工作人员患上职业过敏性接触性皮炎：材料与方法：23 名经常接触 DCC 的实验室工作人员参加了这项研究，其中 21 人患有皮炎，11 人为对照组。所有参与者都接受了不同浓度的 DCC 和工作环境中使用的其他物质的皮肤斑贴测试。研究人员对活动组和对照组的结果进行了统计分析比较：在接受测试的 23 名工人中，56.5% 对 DCC 呈阳性反应。所有这些人都患有皮炎。26.1%的工人对吗啉也呈阳性反应，他们都对 DCC 过敏。二甲基甲酰胺和氯仿呈阴性反应：结论：二环己基碳二亚胺是导致活动组接触性皮炎的主要原因，这表明该公司爆发了对 DCC 的接触性过敏，有必要采取预防措施。DCC 0.1% ac.和 DCC 0.05% pet.都应用于斑贴试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".