Effect of exercise training in patients with angina with nonobstructive coronary arteries: a systematic review and meta-analysis.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Coronary artery disease Pub Date : 2024-10-24 DOI:10.1097/MCA.0000000000001440

Yuan Wu, Haixiang Zhu, Qijin Xu, Yan Li, Leiwen Tang

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引用次数: 0

Abstract

Angina with nonobstructive coronary arteries (ANOCA) is a highly prevalent heart disease. The evidence on exercise training (ET) for the treatment of ANOCA, however, is still inadequate. This meta-analysis aims to provide a comprehensive assessment of the effect of ET in patients with ANOCA. Studies were searched from PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, VIP, and WanFang from inception to 15 January 2024. The quality of included studies was assessed using the Cochrane risk of bias tool. Heterogeneity among the studies was evaluated using Cochran's Q test and I2 statistic, and subgroup analysis based on gender was performed to explore potential sources of heterogeneity. A total of 12 studies were included in this meta-analysis. The pooled results showed that ET significantly increased the peak oxygen uptake (peak VO2) [weighted mean difference (WMD) = 6.11, 95% confidence interval (CI): 4.73 to 7.50], left ventricular ejection fraction (WMD = 7.66, 95% CI: 5.53 to 9.78), and 6 min walking test (WMD = 55.55; 95% CI: 16.23 to 94.87). Nitric oxide (WMD = 20.18, 95% CI: 19.16 to 21.21) and peripheral arterial tonometry (WMD = 0.16, 95% CI: 0.11 to 0.21) were higher, and matrix metalloproteinase-9 (WMD = -8.02, 95% CI: -9.21 to -6.84) was lower in ET group. In conclusion, our findings indicated that ET could improve cardiopulmonary function, exercise capacity, and endothelial function, which could be recommended for the treatment of ANOCA patients.

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运动训练对冠状动脉无阻塞性心绞痛患者的影响：系统综述和荟萃分析。

冠状动脉无阻塞性心绞痛（ANOCA）是一种高发心脏病。然而，有关运动训练（ET）治疗冠心病心绞痛的证据仍然不足。本荟萃分析旨在全面评估 ET 对 ANOCA 患者的影响。从开始到 2024 年 1 月 15 日，我们在 PubMed、Embase、Cochrane Library、Web of Science、中国国家知识基础设施、VIP 和万方数据库中检索了相关研究。使用 Cochrane 偏倚风险工具评估了纳入研究的质量。使用 Cochran's Q 检验和 I2 统计量评估研究之间的异质性，并根据性别进行亚组分析，以探索潜在的异质性来源。本次荟萃分析共纳入了 12 项研究。汇总结果显示，ET 能显著提高峰值摄氧量（峰值 VO2）[加权平均差（WMD）= 6.11，95% 置信区间（CI）：4.73 至 7.50]、左室射血分数（WMD = 7.66，95% CI：5.53 至 9.78）和 6 分钟步行测试（WMD = 55.55；95% CI：16.23 至 94.87）。一氧化氮（WMD = 20.18，95% CI：19.16 至 21.21）和外周动脉测压（WMD = 0.16，95% CI：0.11 至 0.21）在 ET 组较高，基质金属蛋白酶-9（WMD = -8.02，95% CI：-9.21 至 -6.84）在 ET 组较低。总之，我们的研究结果表明，ET可改善心肺功能、运动能力和内皮功能，可推荐用于治疗ANOCA患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Coronary artery disease 医学-外周血管病

CiteScore

2.50

自引率

0.00%

发文量

190

审稿时长

6-12 weeks

期刊介绍： Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management. Submitted artcles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.