Inhibition of JNK/STAT3/NF-KB pathway-mediated migration and clonal formation of lung adenocarcinoma A549 cells by daphnetin.

IF 3.3 3区 生物学 Q3 CELL BIOLOGY
Cell Adhesion & Migration Pub Date : 2024-12-01 Epub Date: 2024-10-29 DOI:10.1080/19336918.2024.2418049
Zhe Lv, Yuna Du, Huiqing Zhang, Hui Fang, Yujie Guo, Lifeng Zeng, Yiguo Chen, Dan Li, Rong Li
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引用次数: 0

Abstract

Daphnetin, a coumarin derivative isolated from Daphne odorifera, has anti-tumor effects. The MAPK, STAT3, and NF-κB signaling pathways are closely related to the pathogenesis of lung cancer. To investigate the effect of daphnetin on anti-lung adenocarcinoma A549 cells and its mechanism. The anti-tumor effects of daphnetin on the proliferation, clone formation, migration, and invasion of A549 lung adenocarcinoma cells were investigated. The results showed that daphnetin inhibited the proliferation, colony formation, migration, and invasion of A549 cells through the MAPK/STAT3/NF-KB pathway, and mainly inhibited the clonal formation and migration of A549 cells through the JNK pathway. These results provide a new research direction and theoretical basis for the use of daphnetin in the inhibition of lung adenocarcinoma.

萘丁抑制 JNK/STAT3/NF-KB 通路介导的肺腺癌 A549 细胞迁移和克隆形成。
Daphnetin 是一种从 Daphne odorifera 中分离出来的香豆素衍生物,具有抗肿瘤作用。MAPK、STAT3 和 NF-κB 信号通路与肺癌的发病机制密切相关。为了研究水飞蓟素对肺腺癌 A549 细胞的抗肿瘤作用及其机制。研究了水飞萘素对 A549 肺腺癌细胞的增殖、克隆形成、迁移和侵袭的抗肿瘤作用。结果表明,水飞萘素通过MAPK/STAT3/NF-KB途径抑制A549细胞的增殖、克隆形成、迁移和侵袭,主要通过JNK途径抑制A549细胞的克隆形成和迁移。这些结果为水飞蓟素用于抑制肺腺癌提供了新的研究方向和理论依据。
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来源期刊
CiteScore
6.40
自引率
0.00%
发文量
7
审稿时长
53 weeks
期刊介绍: Cell Adhesion & Migration is a multi-disciplinary, peer reviewed open access journal that focuses on the biological or pathological implications of cell-cell and cell-microenvironment interactions. The main focus of this journal is fundamental science. The journal strives to serve a broad readership by regularly publishing review articles covering specific disciplines within the field, and by publishing focused issues that provide an overview on specific topics of interest within the field. Cell Adhesion & Migration publishes relevant and timely original research, as well as authoritative overviews, commentaries, and perspectives, providing context for the work presented in Cell Adhesion & Migration and for key results published elsewhere. Original research papers may cover all topics important in the field of cell-cell and cell-matrix interactions. Cell Adhesion & Migration also publishes articles related to cell biomechanics, biomaterial, and development of related imaging technologies.
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