Retrosplenial hypometabolism precedes the conversion from mild cognitive impairment to Alzheimer's disease.

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2024-10-29 DOI:10.1002/alz.14258

Dylan J Terstege, Liisa A M Galea, Jonathan R Epp

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引用次数: 0

Abstract

Introduction: Not all individuals who experience mild cognitive impairment (MCI) transition through progressive stages of cognitive decline at the same rate, if at all. Previous observational studies have identified the retrosplenial cortex (RSC) as an early site of hypometabolism in MCI which seems to be predictive of later transition to Alzheimer's disease (AD).

Methods: We examined N = 399 MCI subjects with baseline ¹⁸F-fluorodeoxyglucose positron emission tomography. Subjects were classified based on whether their diagnosis converted from MCI to AD.

Results: Whole-brain metabolism was decreased in converters (MCI-AD). This effect was more prominent at the RSC, where MCI-AD subjects showed even greater hypometabolism. Observations of RSC hypometabolism and its utility in predicting transition from MCI-AD withstood statistical analyses in a large retrospective study.

Discussion: These results point to the utility of incorporating RSC hypometabolism into predictive models of AD progression risk and call for further examination of mechanisms underlying this relationship.

Highlights: Not all individuals who develop MCI will progress to AD. Individuals with MCI who progress to AD show early whole-brain hypometabolism. Early hypometabolism is particularly prominent at the RSC.

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从轻度认知障碍转变为阿尔茨海默氏症之前，脾后叶代谢功能减退。

导言：并非所有轻度认知功能障碍（MCI）患者都以相同的速度（如果有的话）经历认知功能逐渐衰退的阶段。以往的观察性研究发现，回脾皮质（RSC）是 MCI 早期代谢低下的部位，似乎可预测日后向阿尔茨海默病（AD）的转变：我们对N = 399名MCI受试者进行了基线18F-氟脱氧葡萄糖正电子发射断层扫描检查。我们根据受试者的诊断是否从 MCI 转为 AD 进行了分类：结果：转换者（MCI-AD）的全脑代谢下降。这种影响在RSC更为突出，MCI-AD受试者在RSC的代谢更低。在一项大型回顾性研究中，对RSC代谢低下的观察及其在预测MCI-AD转变中的作用经受住了统计分析的考验：讨论：这些结果表明，将RSC代谢低下纳入AD进展风险预测模型是有用的，并呼吁进一步研究这种关系的内在机制：亮点：并非所有MCI患者都会发展为AD。进展为AD的MCI患者早期会出现全脑代谢低下。早期代谢低下在RSC尤为突出。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.