Shorter duration of Blinatumomab administration to 14 days has same efficacy and safety profile in treatment of relapsed/refractory B-cell precursor acute lymphoblastic leukemia: A retrospective single-center study.

IF 1.7 4区 医学 Q3 HEMATOLOGY
Jinyu Kong, Wenjing Miao, Jialing Lu, Yin Liu, Xin Kong, Huiying Qiu, Baoquan Song
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引用次数: 0

Abstract

Introduction: Treatment of patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia (r/r BCP-ALL) remains a significant clinical challenge. Many new strategies are changing the treatment landscape of r/r BCP-ALL in recent years. Blinatumomab has improved outcomes in r/r BCP-ALL, though high treatment costs and extended hospital stays are significant concerns. We considered that shortening the duration of blinatumomab administration during induction therapy might solve these problems.

Methods: We retrospectively analyzed 19 patients with r/r BCP-ALL treated with different duration of blinatumomab, where 10 patients received blinatumomab for 14 days (Bli 14 D group) and 9 received it for a longer duration (LT group, 21-28 days).

Results: The overall response rate (ORR) was 63.2% (12/19) of patients in total, and the ORR rates in 14 D and LT groups were almost the same (60% and 66.6%, respectively). The median overall survival (OS) was not reached in either groups. The median event-free survival (EFS) time was 4.1 months in LT group and not reached in D14 group. The most common adverse events were consistent with previous reports, including cytokine release syndrome (CRS), neurologic toxicity, and hematological toxicity.

Conclusion: A 14-day blinatumomab administration may be a promising and well-tolerated regimen in r/r BCP-ALL, offering the same ORR and survival rates.

在治疗复发/难治性B细胞前体急性淋巴细胞白血病时,将Blinatumomab的用药时间缩短至14天具有相同的疗效和安全性:一项回顾性单中心研究。
简介:治疗复发/难治性B细胞前体急性淋巴细胞白血病(r/r BCP-ALL)患者仍然是一项重大的临床挑战。近年来,许多新策略正在改变r/r BCP-ALL的治疗格局。Blinatumomab改善了r/r BCP-ALL的治疗效果,但高昂的治疗费用和延长的住院时间也是令人十分担忧的问题。我们认为,在诱导治疗期间缩短 Blinatumomab 的用药时间可能会解决这些问题:我们回顾性分析了19例接受不同时间blinatumomab治疗的r/r BCP-ALL患者,其中10例患者接受了14天的blinatumomab治疗(Bli 14 D组),9例患者接受了更长时间的blinatumomab治疗(LT组,21-28天):总反应率(ORR)为63.2%(12/19),14 D组和LT组的总反应率几乎相同(分别为60%和66.6%)。两组患者均未达到中位总生存期(OS)。LT组的中位无事件生存期(EFS)为4.1个月,而D14组未达到。最常见的不良反应与之前的报道一致,包括细胞因子释放综合征(CRS)、神经毒性和血液毒性:结论:对于r/r BCP-ALL患者,14天的blinatumomab用药可能是一种前景看好且耐受性良好的方案,可提供相同的ORR和生存率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Haematologica
Acta Haematologica 医学-血液学
CiteScore
4.90
自引率
0.00%
发文量
61
审稿时长
6-12 weeks
期刊介绍: ''Acta Haematologica'' is a well-established and internationally recognized clinically-oriented journal featuring balanced, wide-ranging coverage of current hematology research. A wealth of information on such problems as anemia, leukemia, lymphoma, multiple myeloma, hereditary disorders, blood coagulation, growth factors, hematopoiesis and differentiation is contained in first-rate basic and clinical papers some of which are accompanied by editorial comments by eminent experts. These are supplemented by short state-of-the-art communications, reviews and correspondence as well as occasional special issues devoted to ‘hot topics’ in hematology. These will keep the practicing hematologist well informed of the new developments in the field.
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