Cobalt-catalyzed reductive cross-coupling: a review.

IF 3.9 2区化学 Q2 CHEMISTRY, APPLIED

Molecular Diversity Pub Date : 2024-10-28 DOI:10.1007/s11030-024-11017-1

Shamoon Hassan, Muhammad Bilal, Shehla Khalid, Nasir Rasool, Muhammad Imran, Adnan Ali Shah

引用次数: 0

Abstract

Transition-metal-catalyzed reductive cross-coupling is highly efficient for forming C-C bonds. It earns its limelight from its application by coupling unreactive electrophilic substrates to synthesize a variety of carbon-carbon bonds with various hybridizations (sp, sp², and sp³), late-stage functionalization, and bioactive molecules' synthesis. Reductive cross-coupling is challenging to bring selectivity but promising approach. Cobalt is comparatively more affordable than other highly efficient metals e.g., palladium and nickel but cobalt catalysis is still facing efficacy challenges. Researchers are trying to harness the maximum out of cobalt's catalytic properties. Shortly, with efficiency achieved combined with the affordability of cobalt, it will revolutionize industrial applications. This review gives insight into the core of cobalt-catalyzed reductive cross-coupling reactions with a variety of substrates forming a range of differently hybridized coupled products.

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钴催化的还原交叉偶联：综述。

过渡金属催化的还原交叉偶联能高效地形成 C-C 键。它通过将不反应的亲电底物偶联到各种碳-碳键上，从而合成各种杂化（sp、sp2 和 sp3）、后期官能化和生物活性分子。还原交叉偶联是一种具有挑战性的选择性方法，但前景广阔。与其他高效金属（如钯和镍）相比，钴的价格相对较低，但钴催化仍然面临着功效方面的挑战。研究人员正试图最大限度地利用钴的催化特性。不久的将来，随着钴催化效率的提高和价格的降低，它将为工业应用带来革命性的变化。本综述深入探讨了钴催化的还原交叉偶联反应的核心内容，这些反应可与多种底物形成一系列不同的杂化偶联产物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Diversity 化学-化学综合

CiteScore

7.30

自引率

7.90%

发文量

219

审稿时长

2.7 months

期刊介绍： Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including: combinatorial chemistry and parallel synthesis; small molecule libraries; microwave synthesis; flow synthesis; fluorous synthesis; diversity oriented synthesis (DOS); nanoreactors; click chemistry; multiplex technologies; fragment- and ligand-based design; structure/function/SAR; computational chemistry and molecular design; chemoinformatics; screening techniques and screening interfaces; analytical and purification methods; robotics, automation and miniaturization; targeted libraries; display libraries; peptides and peptoids; proteins; oligonucleotides; carbohydrates; natural diversity; new methods of library formulation and deconvolution; directed evolution, origin of life and recombination; search techniques, landscapes, random chemistry and more;