Size effect of ZIF-8 based nanocarrier pesticide delivery system on targeted release and insecticidal activity.

IF 3.8 1区农林科学 Q1 AGRONOMY

Pest Management Science Pub Date : 2024-10-28 DOI:10.1002/ps.8501

Zhou Gao, Jinfang Tan, Yuqing Sun, Xiaoqian Jiang

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引用次数: 0

Abstract

Background: Traditional chemical pesticides are easily lost by surface runoff and only small quantities reach the target, thus causing serious environmental pollution. In this work, dinotefuran@zeolitic imidazolate framework-8@polydopamine@zein (DNF@ZIF-8@PDA@zein), was constructed to deliver DNF with pH and enzyme double response of release, thereby achieving targeted release and efficient long-term pest control.

Results: DNF@ZIF-8@PDA@zein was synthesized with three hydrated diameters (249.73 ± 9.99 nm, 142.94 ± 5.63 nm and 75.16 ± 4.66 nm, respectively). The release of DNF from DNF@ZIF-8@PDA@zein after 28 h was significantly higher at pH 5.0 (89.22 ± 7.18%) compared to that at pH 8 (81.8 ± 6.11%). Protease-assisted release of DNF was notably higher than that without protease (pH 5: 89.22 ± 5.55% versus 27.19 ± 3.22%; pH 8: 81.8 ± 6.11% versus 25.39 ± 3.87%). The stimuli-responsive release of DNF from DNF@ZIF-8@PDA@zein increased with decreased particle size due to increased pore size, reduced binding forces (i.e., weaker π-π stacking, hydrogen bonding, and Zn-N covalent bonding), and the shortening of diffusion path, leading to faster disintegration and drug release. Additionally, the anti-photolysis ability of DNF@ZIF-8@PDA@zein was 3.2 times that of pure DNF. The insecticidal activity improved with smaller nanoparticles due to higher drug release rate and greater inhibition of detoxification enzyme activity by more zinc ion (Zn²⁺) dissolution.

Conclusion: The pH and enzyme dual-responsive release as well as insecticidal activity of DNF@ZIF-8@PDA@zein increase with decreased nanoparticle size, showing effective pest management in long-term and potential application prospects in sustainable agriculture. © 2024 Society of Chemical Industry.

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基于 ZIF-8 的纳米载体农药递送系统对定向释放和杀虫活性的尺寸效应。

背景：传统的化学农药容易随地表径流流失，只有少量到达靶标，造成严重的环境污染。本研究构建了二硝基呋喃@唑基咪唑啉框架-8@聚多巴胺@zein（DNF@ZIF-8@PDA@zein），通过pH值和酶的双重释放响应来释放二硝基呋喃，从而实现靶向释放和长期高效的害虫控制：结果：合成的DNF@ZIF-8@PDA@zein具有三种水合直径（分别为249.73±9.99 nm、142.94±5.63 nm和75.16±4.66 nm）。28 小时后，DNF@ZIF-8@PDA@zein 的 DNF 释放率在 pH 值为 5.0 时（89.22 ± 7.18%）明显高于 pH 值为 8 时（81.8 ± 6.11%）。蛋白酶辅助的 DNF 释放量明显高于无蛋白酶的释放量（pH 5：89.22 ± 5.55% 对 27.19 ± 3.22%；pH 8：81.8 ± 6.11% 对 25.39 ± 3.87%）。随着粒径的减小，DNF@ZIF-8@PDA@zein 中 DNF 的刺激响应释放量增加，这是由于孔径增大，结合力减弱（即π-π堆积、氢键和 Zn-N 共价键作用减弱），扩散路径缩短，导致崩解和药物释放速度加快。此外，DNF@ZIF-8@PDA@zein 的抗光解能力是纯 DNF 的 3.2 倍。由于更高的药物释放率和更多的锌离子（Zn2+）溶解对解毒酶活性的抑制作用，杀虫活性随着纳米颗粒的变小而提高：结论：随着纳米颗粒尺寸的减小，DNF@ZIF-8@PDA@zein 的 pH 值和酶的双响应释放以及杀虫活性也随之提高，显示出长期有效的害虫管理和在可持续农业中的潜在应用前景。© 2024 化学工业协会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pest Management Science 农林科学-昆虫学

CiteScore

7.90

自引率

9.80%

发文量

553

审稿时长

4.8 months

期刊介绍： Pest Management Science is the international journal of research and development in crop protection and pest control. Since its launch in 1970, the journal has become the premier forum for papers on the discovery, application, and impact on the environment of products and strategies designed for pest management. Published for SCI by John Wiley & Sons Ltd.