{"title":"Scalable Macroscopic Engineering from Polymer-Based Nanoscale Building Blocks: Existing Challenges and Emerging Opportunities.","authors":"Derong Lu, Valentin A Bobrin","doi":"10.1021/acs.biomac.4c01212","DOIUrl":null,"url":null,"abstract":"<p><p>Natural materials exhibit exceptional properties due to their hierarchical structures spanning from the nano- to the macroscale. Replicating these intricate spatial arrangements in synthetic materials presents a significant challenge as it requires precise control of nanometric features within large-scale structures. Addressing this challenge depends on developing methods that integrate assembly techniques across multiple length scales to construct multiscale-structured synthetic materials in practical, bulk forms. Polymers and polymer-hybrid nanoparticles, with their tunable composition and structural versatility, are promising candidates for creating hierarchically organized materials. This review highlights advances in scalable techniques for nanoscale organization of polymer-based building blocks within macroscopic structures, including block copolymer self-assembly with additive manufacturing, polymer brush nanoparticles capable of self-assembling into larger, ordered structures, and direct-write colloidal assembly. These techniques offer promising pathways toward the scalable fabrication of materials with emergent properties suited for advanced applications such as bioelectronic interfaces, artificial muscles, and other biomaterials.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":null,"pages":null},"PeriodicalIF":5.5000,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomacromolecules","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acs.biomac.4c01212","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Natural materials exhibit exceptional properties due to their hierarchical structures spanning from the nano- to the macroscale. Replicating these intricate spatial arrangements in synthetic materials presents a significant challenge as it requires precise control of nanometric features within large-scale structures. Addressing this challenge depends on developing methods that integrate assembly techniques across multiple length scales to construct multiscale-structured synthetic materials in practical, bulk forms. Polymers and polymer-hybrid nanoparticles, with their tunable composition and structural versatility, are promising candidates for creating hierarchically organized materials. This review highlights advances in scalable techniques for nanoscale organization of polymer-based building blocks within macroscopic structures, including block copolymer self-assembly with additive manufacturing, polymer brush nanoparticles capable of self-assembling into larger, ordered structures, and direct-write colloidal assembly. These techniques offer promising pathways toward the scalable fabrication of materials with emergent properties suited for advanced applications such as bioelectronic interfaces, artificial muscles, and other biomaterials.
期刊介绍:
Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine.
Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.