Biosynthesis of pH-Responsive Mesoporous Silica Nanoparticles from Cucumber Peels for Targeting 3D Lung Tumor Spheroids.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Tamanna Bhuyan, Konika Choudhury, Pranjoli Das, Sanathoibi Sharma, Jahirul Ahmed Mazumder, Yugal Kishore Mohanta
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Abstract

Lung adenocarcinoma is considered to be one of the primary causes of cancer-related deaths globally. Conventional treatments, such as chemotherapy and radiation therapy taken together, have not significantly lowered mortality rates. Repositioning of authorized anticancer medications supported by nanotechnology has therefore emerged as an effective strategy to close such gaps. In this context, mesoporous silica nanoparticles (MSNs) were biosynthesized from cucumber peels and were loaded with doxorubicin, a common anticancer drug to form doxorubicin-bound mesoporous silica nanoparticles (DMSNs). The study addresses a sustainable method for turning waste materials into MSNs, which can be used to create multifunctional nanosystems. The therapeutic module (DMSNs) was designed specifically to target 2D monolayer cells and 3D tumor spheroids of lung adenocarcinoma cancer. The DMSNs demonstrated notable antiproliferative activity and effective intracellular localization in addition to being biocompatible and innately fluorescent. Subsequent investigations revealed significant antibacterial activity against Staphylococcal infection, which is primarily prevalent in lung cancer patients. Thus, the developed MSNs held promising potential for anticancer drug delivery systems and have antibacterial potential to treat bacterial infections in patients with lung cancer. Furthermore, the cucumber peel-mediated synthesis of MSNs could also aid in the management of food waste and promote the adoption of the waste-to-health paradigm for sustainable solutions.

从黄瓜皮中生物合成具有 pH 值响应性的介孔二氧化硅纳米颗粒,用于靶向三维肺部肿瘤球茎。
肺腺癌被认为是全球癌症相关死亡的主要原因之一。化疗和放疗等常规治疗方法并未显著降低死亡率。因此,在纳米技术的支持下对已获授权的抗癌药物进行重新定位,已成为缩小这种差距的有效策略。在此背景下,研究人员从黄瓜皮中生物合成了介孔二氧化硅纳米颗粒(MSNs),并在其中添加了常见的抗癌药物多柔比星,形成了多柔比星结合介孔二氧化硅纳米颗粒(DMSNs)。这项研究采用了一种可持续的方法,将废弃材料转化为介孔二氧化硅纳米颗粒,用于制造多功能纳米系统。治疗模块(DMSNs)是专门针对肺腺癌的二维单层细胞和三维肿瘤球体而设计的。DMSNs 具有显著的抗增殖活性和有效的细胞内定位,此外还具有生物相容性和天然荧光性。随后的研究表明,这种物质对主要在肺癌患者中流行的葡萄球菌感染具有显著的抗菌活性。因此,所开发的 MSNs 有望成为抗癌药物输送系统,并具有治疗肺癌患者细菌感染的抗菌潜力。此外,黄瓜皮介导的 MSNs 合成还有助于食物垃圾的管理,并促进采用 "变废为宝 "的可持续解决方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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