Semiaromatic Polyester-Ethers with Tunable Degradation Profiles.

IF 5.1 Q1 POLYMER SCIENCE

ACS Macro Letters Pub Date : 2024-11-19 Epub Date: 2024-10-28 DOI:10.1021/acsmacrolett.4c00617

Nicola G Judge, Maddison I Segal, Robert O Silzer, Courtney S Dziewior, Yin Mei Chan, Sawyer J Grovogel, Matthew L Becker

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Abstract

Poly(ε-caprolactone) (PCL) is a widely utilized polymer within the biomedical field; however, one of its limitations is the multi-year long degradation profile. Herein, we report a semiaromatic polyester-ether (SAEE) PCL copolymer using a salicylic acid-based monomer which can disrupt the semicrystalline nature of the bulk material. The molar percentage of incorporation correlated to a linear decrease in melting and crystallization temperature, until a totally amorphous solid was seen at 37 mol %. Alongside this, mechanical analysis elucidated a softer, more extensible material with E' decreasing from 292 to 222 to 43.8 MPa for PCL to 10 to 22 mol % SAEE, respectively. Accelerated basic degradation studies (2 M NaOH) exhibited total mass loss after 16 weeks for 6 mol % compared to only 38% mass loss for PCL over the same period. Overall, by varying the SAEE mol %, we show the ability to finely tune the thermal, mechanical, and degradation profiles of PCL copolymers while maintaining an advantageous biological profile.

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降解曲线可调的半芳香聚酯醚。

聚(ε-己内酯)（PCL）是一种在生物医学领域广泛使用的聚合物，但其局限性之一是多年的降解过程。在此，我们报告了一种半自动聚酯醚（SAEE）PCL 共聚物，它使用了一种水杨酸基单体，这种单体可以破坏块状材料的半结晶性质。加入的摩尔百分比与熔化和结晶温度的线性下降相关，直到摩尔百分比为 37 时才出现完全无定形的固体。与此同时，机械分析表明，PCL 的 E' 值从 292 兆帕下降到 222 兆帕，SAEE 的 E' 值从 10 摩尔%下降到 22 摩尔%，达到 43.8 兆帕，材料变得更柔软、更具延展性。加速基本降解研究（2 M NaOH）显示，6 摩尔/% 的材料在 16 周后会出现全部质量损失，而 PCL 在同一时期的质量损失仅为 38%。总之，通过改变 SAEE 的摩尔百分比，我们展示了在保持有利的生物特性的同时，对 PCL 共聚物的热、机械和降解特性进行微调的能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Macro Letters 化学-

CiteScore

10.40

自引率

3.40%

发文量

209

审稿时长

1 months

期刊介绍： ACS Macro Letters publishes research in all areas of contemporary soft matter science in which macromolecules play a key role, including nanotechnology, self-assembly, supramolecular chemistry, biomaterials, energy generation and storage, and renewable/sustainable materials. Submissions to ACS Macro Letters should justify clearly the rapid disclosure of the key elements of the study. The scope of the journal includes high-impact research of broad interest in all areas of polymer science and engineering, including cross-disciplinary research that interfaces with polymer science. With the launch of ACS Macro Letters, all Communications that were formerly published in Macromolecules and Biomacromolecules will be published as Letters in ACS Macro Letters.