Causal inference for epigenetic ageing

IF 39.1 1区生物学 Q1 GENETICS & HEREDITY

Nature Reviews Genetics Pub Date : 2024-10-29 DOI:10.1038/s41576-024-00799-7

Kejun Ying

引用次数: 0

Abstract

In this Tools of the Trade article, Kejun Ying describes epigenome-wide Mendelian randomization, which integrates Mendelian randomization into a DNA-methylation-based epigenetic clock to identify CpG sites with potential causal links to lifespan and healthspan.

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表观遗传老化的因果推理

在这篇 "贸易工具"（Tools of the Trade）文章中，Kejun Ying介绍了全表观基因组孟德尔随机化（epigenome-wide Mendelian randomization），该方法将孟德尔随机化与基于DNA甲基化的表观遗传时钟相结合，以鉴定与寿命和健康寿命有潜在因果关系的CpG位点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Genetics 生物-遗传学

CiteScore

57.40

自引率

0.50%

发文量

113

审稿时长

6-12 weeks

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