NIR-II scattering gold superclusters for intravascular optical coherence tomography molecular imaging

IF 38.1 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Nature nanotechnology Pub Date : 2024-10-28 DOI:10.1038/s41565-024-01802-2

Nicholas D. Calvert, Joshua Baxter, Aidan A. Torrens, Jesse Thompson, Alexia Kirby, Jaspreet Walia, Spyridon Ntais, Eva Hemmer, Pierre Berini, Benjamin Hibbert, Lora Ramunno, Adam J. Shuhendler

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Abstract

Currently, intravascular optical coherence tomography (IV-OCT) is limited to anatomical imaging, providing structural information about atherosclerotic plaque morphology, thrombus and dissection. Earlier detection and risk stratification would be possible through molecular characterization of endothelium but necessitates a purpose-engineered IV-OCT contrast agent. Here we developed gold superclusters (AuSCs) tailored to clinical instrumentation and integrated into clinically relevant workflows. AuSCs are aqueously dispersible clusters of closely packed small gold nanoparticles, affording plasmon hybridization to maximize light scattering at the IV-OCT laser line (~1,350 nm). A polymer coating fosters AuSC uniformity and provides a functionalizable handle, which we targeted to intravascular P-selectin, an early vascular endothelial marker of inflammation. In a rat model of intravascular inflammation, P-selectin-targeted AuSC facilitated IV-OCT molecular imaging, where the strength of the signal correlates with the severity of vascular inflammation.

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用于血管内光学相干断层扫描分子成像的近红外-II 散射金超簇

目前，血管内光学相干断层扫描（IV-OCT）仅限于解剖成像，提供有关动脉粥样硬化斑块形态、血栓和夹层的结构信息。通过内皮的分子特征描述可以实现早期检测和风险分层，但这需要一种专门设计的 IV-OCT 造影剂。在此，我们开发了专为临床仪器定制的金超集束物（AuSCs），并将其整合到临床相关的工作流程中。AuSCs 是由紧密排列的小金纳米颗粒组成的水性分散团簇，具有等离子体杂化作用，可最大限度地提高 IV-OCT 激光线（约 1,350 纳米）的光散射。聚合物涂层促进了 AuSC 的均匀性，并提供了一个可功能化的手柄，我们将其与血管内 P-选择素（一种早期血管内皮炎症标志物）靶向。在大鼠血管内炎症模型中，P-选择素靶向 AuSC 促进了 IV-OCT 分子成像，其信号强度与血管炎症的严重程度相关。

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来源期刊

Nature nanotechnology 工程技术-材料科学：综合

CiteScore

59.70

自引率

0.80%

发文量

196

审稿时长

4-8 weeks

期刊介绍： Nature Nanotechnology is a prestigious journal that publishes high-quality papers in various areas of nanoscience and nanotechnology. The journal focuses on the design, characterization, and production of structures, devices, and systems that manipulate and control materials at atomic, molecular, and macromolecular scales. It encompasses both bottom-up and top-down approaches, as well as their combinations. Furthermore, Nature Nanotechnology fosters the exchange of ideas among researchers from diverse disciplines such as chemistry, physics, material science, biomedical research, engineering, and more. It promotes collaboration at the forefront of this multidisciplinary field. The journal covers a wide range of topics, from fundamental research in physics, chemistry, and biology, including computational work and simulations, to the development of innovative devices and technologies for various industrial sectors such as information technology, medicine, manufacturing, high-performance materials, energy, and environmental technologies. It includes coverage of organic, inorganic, and hybrid materials.