A temperature, pH, and ion sensitive block copolymer with an unusual phase transition: Monomethoxy polyethylene glycol—block-polyethyleneimine

IF 2.6 4区 化学 Q3 POLYMER SCIENCE
Kadriye Özlem Hamaloğlu, Hacim Kosaoğlu, Ali Tuncel, Serdar S. Çelebi
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Abstract

A temperature, pH and ion sensitive, block copolymer, monomethoxypolyethylene glycol (MPEG)–block-polyethyleneimine (PEI) was synthesized by carbodiimide activation. MPEG-PEI block copolymer exhibited a thermally reversible phase transition from insoluble to soluble form with increasing temperature at neutral pH. MPEG-PEI chains are insoluble in the temperature range of 4–20 °C in an aqueous medium containing 3.5 mM phosphate ion. By increasing temperature, homogeneous and transparent solutions including dissolved copolymer are obtained at temperatures higher than 20 °C. The observed thermoresponsive behavior was opposite to that seen with poly(N-isopropylacrylamide). Depending on the phosphate ion concentration, the phase transition temperature for passing from insoluble to soluble form could be also precisely controlled between 4–40 °C. The reversible phase transition behavior of MPEG-PEI copolymer was confirmed by ten consecutive heating–cooling cycles between 4—50 °C. MPEG-PEI copolymer also exhibited another responsivity against pH. More appreciable increase in the average hydrodynamic size with the rising temperature was observed at pH 9.0 with respect to those obtained at pH 5 and 7. Temperature, pH and ion sensitive behavior of MPEG-PEI is documented for the first time. The reversible phase transition of MPEG-PEI is a promising tool which may open novel pathways, particularly for enzyme immobilization and drug release studies.

Abstract Image

一种对温度、pH 值和离子敏感的嵌段共聚物,具有不寻常的相变:单甲氧基聚乙二醇-嵌段-聚乙烯亚胺
通过碳二亚胺活化法合成了一种对温度、pH 值和离子敏感的嵌段共聚物--单甲氧基聚乙二醇(MPEG)-嵌段聚乙烯亚胺(PEI)。在中性 pH 值下,MPEG-PEI 嵌段共聚物随着温度的升高呈现出从不溶物到可溶物的热可逆相变。在含有 3.5 mM 磷酸盐离子的水介质中,MPEG-PEI 链在 4-20 °C 的温度范围内不溶解。随着温度的升高,在温度高于 20 ℃ 时会得到均匀透明的溶液,其中包括溶解的共聚物。观察到的热致伸缩行为与聚(N-异丙基丙烯酰胺)的热致伸缩行为相反。根据磷酸根离子浓度的不同,从不溶物到可溶物的相变温度也可精确控制在 4-40 ℃ 之间。MPEG-PEI 共聚物的可逆相变行为通过在 4-50 ℃ 之间连续十次加热-冷却循环得到了证实。MPEG-PEI 共聚物还表现出对 pH 值的另一种反应性。与 pH 值为 5 和 7 时相比,在 pH 值为 9.0 时,随着温度的升高,平均流体力学尺寸的增加更为明显。这是首次记录 MPEG-PEI 对温度、pH 值和离子敏感的行为。MPEG-PEI 的可逆相变是一种很有前途的工具,它可以开辟新的途径,特别是在酶固定和药物释放研究方面。
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来源期刊
Journal of Polymer Research
Journal of Polymer Research 化学-高分子科学
CiteScore
4.70
自引率
7.10%
发文量
472
审稿时长
3.6 months
期刊介绍: Journal of Polymer Research provides a forum for the prompt publication of articles concerning the fundamental and applied research of polymers. Its great feature lies in the diversity of content which it encompasses, drawing together results from all aspects of polymer science and technology. As polymer research is rapidly growing around the globe, the aim of this journal is to establish itself as a significant information tool not only for the international polymer researchers in academia but also for those working in industry. The scope of the journal covers a wide range of the highly interdisciplinary field of polymer science and technology, including: polymer synthesis; polymer reactions; polymerization kinetics; polymer physics; morphology; structure-property relationships; polymer analysis and characterization; physical and mechanical properties; electrical and optical properties; polymer processing and rheology; application of polymers; supramolecular science of polymers; polymer composites.
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