Kadriye Özlem Hamaloğlu, Hacim Kosaoğlu, Ali Tuncel, Serdar S. Çelebi
{"title":"A temperature, pH, and ion sensitive block copolymer with an unusual phase transition: Monomethoxy polyethylene glycol—block-polyethyleneimine","authors":"Kadriye Özlem Hamaloğlu, Hacim Kosaoğlu, Ali Tuncel, Serdar S. Çelebi","doi":"10.1007/s10965-024-04182-2","DOIUrl":null,"url":null,"abstract":"<div><p>A temperature, pH and ion sensitive, block copolymer, monomethoxypolyethylene glycol (MPEG)–block-polyethyleneimine (PEI) was synthesized by carbodiimide activation. MPEG-PEI block copolymer exhibited a thermally reversible phase transition from insoluble to soluble form with increasing temperature at neutral pH. MPEG-PEI chains are insoluble in the temperature range of 4–20 °C in an aqueous medium containing 3.5 mM phosphate ion. By increasing temperature, homogeneous and transparent solutions including dissolved copolymer are obtained at temperatures higher than 20 °C. The observed thermoresponsive behavior was opposite to that seen with poly(N-isopropylacrylamide). Depending on the phosphate ion concentration, the phase transition temperature for passing from insoluble to soluble form could be also precisely controlled between 4–40 °C. The reversible phase transition behavior of MPEG-PEI copolymer was confirmed by ten consecutive heating–cooling cycles between 4—50 °C. MPEG-PEI copolymer also exhibited another responsivity against pH. More appreciable increase in the average hydrodynamic size with the rising temperature was observed at pH 9.0 with respect to those obtained at pH 5 and 7. Temperature, pH and ion sensitive behavior of MPEG-PEI is documented for the first time. The reversible phase transition of MPEG-PEI is a promising tool which may open novel pathways, particularly for enzyme immobilization and drug release studies.</p></div>","PeriodicalId":658,"journal":{"name":"Journal of Polymer Research","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Polymer Research","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10965-024-04182-2","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0
Abstract
A temperature, pH and ion sensitive, block copolymer, monomethoxypolyethylene glycol (MPEG)–block-polyethyleneimine (PEI) was synthesized by carbodiimide activation. MPEG-PEI block copolymer exhibited a thermally reversible phase transition from insoluble to soluble form with increasing temperature at neutral pH. MPEG-PEI chains are insoluble in the temperature range of 4–20 °C in an aqueous medium containing 3.5 mM phosphate ion. By increasing temperature, homogeneous and transparent solutions including dissolved copolymer are obtained at temperatures higher than 20 °C. The observed thermoresponsive behavior was opposite to that seen with poly(N-isopropylacrylamide). Depending on the phosphate ion concentration, the phase transition temperature for passing from insoluble to soluble form could be also precisely controlled between 4–40 °C. The reversible phase transition behavior of MPEG-PEI copolymer was confirmed by ten consecutive heating–cooling cycles between 4—50 °C. MPEG-PEI copolymer also exhibited another responsivity against pH. More appreciable increase in the average hydrodynamic size with the rising temperature was observed at pH 9.0 with respect to those obtained at pH 5 and 7. Temperature, pH and ion sensitive behavior of MPEG-PEI is documented for the first time. The reversible phase transition of MPEG-PEI is a promising tool which may open novel pathways, particularly for enzyme immobilization and drug release studies.
期刊介绍:
Journal of Polymer Research provides a forum for the prompt publication of articles concerning the fundamental and applied research of polymers. Its great feature lies in the diversity of content which it encompasses, drawing together results from all aspects of polymer science and technology.
As polymer research is rapidly growing around the globe, the aim of this journal is to establish itself as a significant information tool not only for the international polymer researchers in academia but also for those working in industry. The scope of the journal covers a wide range of the highly interdisciplinary field of polymer science and technology, including:
polymer synthesis;
polymer reactions;
polymerization kinetics;
polymer physics;
morphology;
structure-property relationships;
polymer analysis and characterization;
physical and mechanical properties;
electrical and optical properties;
polymer processing and rheology;
application of polymers;
supramolecular science of polymers;
polymer composites.