Reaction of bismuth(iii) chloride with N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2024-10-26 DOI:10.1007/s11172-024-4378-4

T. P. Trofimova, V. A. Tafeenko, A. S. Borodkov, A. N. Proshin, A. A. Evdokimov, M. A. Orlova

引用次数: 0

Abstract

A new bismuth complex with the N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide ligand (L = C₁₁H₁₃N₂OS) was synthesized for further medical use. The complex and the ligand exhibit anticancer activity. The structure of the complex was characterized by NMR spectroscopy, inductively coupled plasma atomic emission spectroscopy (ICP-AES), and laser-induced electron transfer desorption/ionization (LETDI) mass spectrometry. The Bi: L ratio is 1: 1; the components are connected by an ionic (ion-dipole) interaction. The reaction of bismuth(iii) chloride with ligand hydrobromide (L•HBr) affords the complex {(C₁₁H₁₃N₂OS)₃[Bi₂Cl₉]}. The composition of this complex was confirmed by X-ray diffraction, ICP-AES, and LETDI methods.

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氯化铋(iii)与 N-(5,6-二氢-4H-1,3-噻嗪-2-基)苯甲酰胺的反应

我们合成了一种新的铋配合物与 N-(5,6-二氢-4H-1,3-噻嗪-2-基)苯甲酰胺配体（L = C11H13N2OS），用于进一步的医疗用途。该配合物和配体具有抗癌活性。利用核磁共振光谱、电感耦合等离子体原子发射光谱（ICP-AES）和激光诱导电子转移解吸/电离（LETDI）质谱对该配合物的结构进行了表征。Bi：L 比率为 1:1；各组分通过离子（离子-偶极子）相互作用连接。氯化铋(iii)与配体氢溴酸盐（L-HBr）反应生成络合物 {(C11H13N2OS)3[Bi2Cl9]}。通过 X 射线衍射、ICP-AES 和 LETDI 方法确认了该复合物的成分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.