PMA-Zeolite: Chemistry and Diverse Medical Applications.

IF 5 3区 医学 Q1 ENGINEERING, BIOMEDICAL
Aleksandar Bulog, Kresimir Pavelic, Ivana Šutić, Sandra Kraljevic Pavelic
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Abstract

Numerous scientific studies have been conducted in recent decades with the aim to study targeted application of zeolites in various industries, ecology, agronomy and medicine. The biggest advances, however, have been documented in medical and veterinary research of the natural zeolite, clinoptilolite. Although the exact biological mechanisms of action of the zeolite clinoptilolite are not completely elucidated, obtained results point to its antioxidative, immunomodulatory and detoxifying effects, the latter partially based on release of soluble and bioavailable silica forms from the surface material. The studied zeolite clinoptilolite materials have different geographical origins which confer to the physicochemical differences in the material. In addition, the production process of the material for oral applications differs between different producers which also accounts for different properties of the surface upon mechanical activation. Recently, a well-characterized zeolite clinoptilolite material, namely the PMA-zeolite, has been tested in different clinical applications and has shown potential as supportive therapy in inflammatory conditions, osteoporosis as well as during tumor chemotherapy. We accordingly present a comprehensive review of the PMA-zeolite effects in the clinical applications and discuss its probable mechanisms of effect in vivo.

PMA-沸石:化学与多种医学应用。
近几十年来,为了研究沸石在各行各业、生态学、农学和医学中的针对性应用,开展了大量科学研究。不过,最大的进展是对天然沸石--clinoptilolite 的医学和兽医学研究。虽然沸石 "clinoptilolite "的确切生物作用机制尚未完全阐明,但已获得的研究结果表明,它具有抗氧化、免疫调节和解毒作用,后者部分是基于从表面材料中释放可溶性和生物可利用的二氧化硅形式。所研究的沸石clinoptilolite 材料具有不同的地理来源,这导致了材料的物理化学差异。此外,不同生产商用于口腔应用的材料的生产工艺也不尽相同,这也是造成机械活化时表面性质不同的原因。最近,一种特性良好的沸石材料,即 PMA-沸石,已经在不同的临床应用中进行了测试,并显示出在炎症、骨质疏松症以及肿瘤化疗期间作为辅助疗法的潜力。因此,我们对 PMA-zeolite 在临床应用中的效果进行了全面回顾,并讨论了其在体内的可能作用机制。
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来源期刊
Journal of Functional Biomaterials
Journal of Functional Biomaterials Engineering-Biomedical Engineering
CiteScore
4.60
自引率
4.20%
发文量
226
审稿时长
11 weeks
期刊介绍: Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.
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