Roles of K(H)SRP in modulating gene transcription throughout cancer progression: Insights from cellular studies to clinical perspectives

IF 9.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-11-01 DOI:10.1016/j.bbcan.2024.189202

Yi-Chieh Yang , Kuo-Hao Ho , Kuo-Tai Hua , Ming-Hsien Chien

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引用次数: 0

Abstract

The KH-type splicing regulatory protein (KHSRP), also known as KSRP, is an RNA-binding protein that regulates gene expressions through various mechanisms, including messenger (m)RNA degradation, micro (mi)RNA maturation, and transcriptional activity. KSRP has been implicated in a wide range of physiological and pathological processes, with emerging evidence highlighting its role in modulating diverse aspects of cancer behaviors. In this review, we provide a comprehensive overview of KSRP's clinical relevance and its multifaceted regulatory mechanisms in cancer. Our extensive pan-cancer analysis uncovers associations of KSRP with clinical outcomes and identifies cell cycle progression as a key signaling pathway correlated with KSRP expression. Furthermore, we identify miR-17-5p as critical miRNAs positively correlated with KSRP, and it is associated with poor survival in various cancers. Collectively, this review offers new insights into the potential of KSRP as a target for therapeutic strategies in cancer treatment.

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K(H)SRP 在整个癌症进展过程中调节基因转录的作用：从细胞研究到临床观点的启示。

KH 型剪接调控蛋白（KHSRP），又称 KSRP，是一种 RNA 结合蛋白，通过各种机制调控基因表达，包括信使 (m)RNA 降解、微 (mi)RNA 成熟和转录活性。KSRP 与多种生理和病理过程都有关联，新出现的证据强调了它在调节癌症行为的不同方面所起的作用。在这篇综述中，我们全面概述了 KSRP 的临床相关性及其在癌症中的多方面调控机制。我们广泛的泛癌症分析发现了 KSRP 与临床结果的关联，并确定细胞周期进展是与 KSRP 表达相关的关键信号通路。此外，我们还发现 miR-17-5p 是与 KSRP 呈正相关的关键 miRNA，它与各种癌症的不良生存率相关。总之，本综述为 KSRP 作为癌症治疗策略靶点的潜力提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学

CiteScore

17.20

自引率

0.00%

发文量

138

审稿时长

33 days

期刊介绍： Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.