Percutaneous endoscopic gastrostomy helped to normalise feeding problems and gastrointestinal symptoms in Silver-Russell syndrome.

IF 2.4 4区 医学 Q1 PEDIATRICS
Acta Paediatrica Pub Date : 2024-10-25 DOI:10.1111/apa.17474
Nataliia Muz, Miriam Petersson, Robert Saalman, Jovanna Dahlgren
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引用次数: 0

Abstract

Aim: This study evaluated feeding problems and gastrointestinal symptoms in children with Silver-Russell syndrome (SRS), which is a rare epigenetic disorder. It also compared the symptoms experienced during different feeding methods, including percutaneous endoscopic gastrostomy (PEG).

Methods: The national expert team for children with SRS at Queen Silvia Children's Hospital, Gothenburg, studied 46 referrals (63% male) who were born with SRS in Sweden from 1984 to 2018. Patient data were extracted from the Paediatric National Growth Hormone Registry.

Results: The medical records covered a median of 68% of the time of the patients' childhood, with a median follow-up of 9 years. Their symptoms were most prevalent during infancy and decreased when they were toddlers. Feeding problems and gastrointestinal symptoms were reported in 91% of the 46 patients, with vomiting in 57% and constipation in 46%. There were 19 children who relied on enteral feeding for their nutrition and 13 of those received PEG. Their body mass index (BMI) increased significantly 2 years after PEG started (p = 0.005).

Conclusion: Feeding problems and gastrointestinal symptoms were very common in children with SRS, but partly disappeared during childhood. Providing treatment, such as PEG, normalised the BMIs of children with SRS and reduced their symptoms.

经皮内窥镜胃造口术有助于改善银-鲁塞尔综合症患者的进食问题和胃肠道症状。
目的:本研究评估了银-鲁塞尔综合征(SRS)患儿的喂养问题和胃肠道症状,SRS是一种罕见的表观遗传性疾病。研究还比较了不同喂养方法(包括经皮内镜胃造口术(PEG))下出现的症状:哥德堡西尔维娅皇后儿童医院SRS患儿国家专家组研究了1984年至2018年期间瑞典出生的46名SRS转诊患者(63%为男性)。患者数据来自儿科国家生长激素登记处:医疗记录覆盖了患者68%的童年时间,中位随访时间为9年。他们的症状在婴儿期最为普遍,幼儿期有所减少。据报告,46 名患者中有 91% 出现喂养问题和胃肠道症状,其中 57% 出现呕吐,46% 出现便秘。有 19 名患儿依靠肠内喂养获得营养,其中 13 名患儿接受了胃肠造影术(PEG)。他们的体重指数(BMI)在 PEG 开始 2 年后显著增加(p = 0.005):结论:喂养问题和胃肠道症状在 SRS 患儿中非常常见,但在儿童期已部分消失。通过 PEG 等治疗,SRS 患儿的体重指数趋于正常,症状也有所减轻。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Paediatrica
Acta Paediatrica 医学-小儿科
CiteScore
6.50
自引率
5.30%
发文量
384
审稿时长
2-4 weeks
期刊介绍: Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries
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