Analysis of Henle's fiber layer and outer retinal layers in cone dystrophy.

IF 2.3 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-10-16 DOI:10.1097/IAE.0000000000004306

Cem Kesim, Selahattin Cansiz, Umit Yasar Guleser, Cigdem Gunduz-Demir, Murat Hasanreisoglu

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引用次数: 0

Abstract

Purpose: To evaluate Henle's Fiber Layer (HFL) thickness and volume parameters in patients with cone photoreceptor atrophy with directional optical coherence tomography (D-OCT).

Methods: Macular 20°×20° standard and D-OCT images were acquired from patients diagnosed with hereditary cone dystrophy with evident foveal ellipsoid zone defect in OCT, and age-matched healthy controls. Thickness and volume parameters of HFL, outer nuclear layer (ONL) and retinal layers between ellipsoid zone and Bruch membrane complex (EZ-BM) were calculated from manual segmentation through D-OCT images and comparative analysis is performed.

Results: Twelve eyes of 6 patients were compared to 12 eyes of 6 age-matched healthy controls (mean age: 29.5±16.6 and 26.6±3.9 years respectively; P=0.162). Patients had lower total HFL volume (0.45±0.03 and 0.85±0.15 mm3; P<0.001) and mean HFL thickness (16.1±1.1 and 30.1±5.3 µm; P<0.001) than healthy controls. Central subfield, parafoveal and perifoveal ETDRS zone HFL parameters in patients were significantly lower than healthy controls. A centrifugal correlation was found between central ONL and the corresponding parafoveal HFL (Spearman's rho: 0.785; P<0.001).

Conclusion: HFL assessment might be a useful OCT biomarker in patients with cone photoreceptor atrophy. HFL thinning is observed in foveal, parafoveal and perifoveal areas of patients with cone photoreceptor atrophy, while volume reduction in ONL and EZ-BM components were limited to central and parafoveal zones.

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分析锥体营养不良症的亨勒纤维层和视网膜外层。

目的：通过定向光学相干断层扫描（D-OCT）评估锥体感光细胞萎缩患者亨氏纤维层（HFL）的厚度和体积参数：方法：采集被诊断为遗传性锥状体营养不良且在 OCT 中具有明显眼窝椭圆形区缺损的患者和年龄匹配的健康对照组的黄斑 20°×20° 标准和 D-OCT 图像。通过手动分割 D-OCT 图像，计算出 HFL、核外层（ONL）以及椭圆带和布鲁氏膜复合体（EZ-BM）之间视网膜层的厚度和体积参数，并进行比较分析：将 6 名患者的 12 只眼睛与 6 名年龄匹配的健康对照者的 12 只眼睛进行比较（平均年龄分别为 29.5±16.6 岁和 26.6±3.9 岁；P=0.162）。患者的 HFL 总体积较低（分别为 0.45±0.03 和 0.85±0.15 mm3；PC 结论：HFL 评估可能是一种有用的 OCT 分析方法：HFL评估可能是锥体感光细胞萎缩患者的一种有用的OCT生物标志物。在锥体感光细胞萎缩患者的眼窝、眼旁和眼周区域观察到HFL变薄，而ONL和EZ-BM成分的体积减少仅限于中央区和眼旁区。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.