The Role of Global Longitudinal Strain in Predicting Left Ventricular Reverse Remodeling After Mitral Valve Replacement Surgery in Patients With Primary Mitral Regurgitation

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques Pub Date : 2024-10-23 DOI:10.1111/echo.15950

Liem Audi Natalino, Real Kusumanjaya Marsam, Lucia Kris Dinarti, Hasanah Mumpuni, Dyah Wulan Anggrahini

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引用次数: 0

Abstract

Objectives

This study aimed to identify the utility of global longitudinal strain (GLS) as a reliable parameter that can accurately forecast left ventricle reverse remodeling (LVRR) in patients undergoing valve replacement surgery for severe chronic primary mitral regurgitation (MR), thereby aiding in assessing mortality and morbidity risk.

Methods

This retrospective observational study involved severe primary MR patients who underwent valve replacement surgery between 2018 and 2023. Pre- and postsurgery echocardiography data were collected, with GLS measurements utilized to assess left ventricular function. Various echocardiography parameters, including MR severity and LV dimensions, were analyzed. Bivariate and multivariate analyses were performed to explore relationships between GLS and LVRR.

Results

This study enrolled 103 patients (54.4% male; mean age 45.4 ± 13.6 years). Statistical analyses revealed GLS to be an independent predictor of LVRR, with a threshold of −16.25% showing 89% sensitivity and 50% specificity. Each 1% increase in GLS corresponded to a 1.14-fold (odds ratio [OR]: 1.14; 95% confidence interval [CI]: 1.01–1.31; p < 0.05) increased likelihood of LVRR.

Conclusion

These findings highlight GLS's potential as a prognostic marker for postsurgical outcomes in severe MR patients.

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整体纵向应变在预测原发性二尖瓣反流患者二尖瓣置换手术后左心室反向重塑中的作用

研究目的本研究旨在确定全局纵向应变（GLS）作为一个可靠参数的实用性，该参数可准确预测因严重慢性原发性二尖瓣反流（MR）而接受瓣膜置换手术的患者的左心室反向重构（LVRR）情况，从而帮助评估死亡率和发病风险：这项回顾性观察研究涉及2018年至2023年期间接受瓣膜置换手术的严重原发性MR患者。收集了手术前和手术后的超声心动图数据，并利用 GLS 测量来评估左心室功能。分析了各种超声心动图参数，包括 MR 严重程度和左心室尺寸。进行双变量和多变量分析以探讨 GLS 和 LVRR 之间的关系：该研究共纳入 103 名患者（54.4% 为男性；平均年龄为 45.4 ± 13.6 岁）。统计分析显示，GLS 是 LVRR 的独立预测指标，阈值为 -16.25%，敏感性为 89%，特异性为 50%。GLS 每增加 1%，LVRR 就会增加 1.14 倍（几率比 [OR]：1.14；95% 置信区间 [CI]：1.01-1.31; p 结论：这些发现凸显了 GLS 作为严重 MR 患者手术后预后标志物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques 医学-心血管系统

CiteScore

2.40

自引率

6.70%

发文量

211

审稿时长

3-6 weeks

期刊介绍： Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques is the official publication of the International Society of Cardiovascular Ultrasound. Widely recognized for its comprehensive peer-reviewed articles, case studies, original research, and reviews by international authors. Echocardiography keeps its readership of echocardiographers, ultrasound specialists, and cardiologists well informed of the latest developments in the field.