Altered neural activities during emotion regulation in depression: a meta-analysis.

IF 4.1 2区 医学 Q2 NEUROSCIENCES
Journal of Psychiatry & Neuroscience Pub Date : 2024-10-25 Print Date: 2024-09-01 DOI:10.1503/jpn.240046
Dihua Wu, Jingxuan Li, Junjing Wang
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引用次数: 0

Abstract

Background: Deficient neural activities during emotion regulation have been reported in depression. We sought to conduct a meta-analysis to provide a comprehensive description of these neural alterations during use of emotion regulation strategies among patients with depression, including major depressive disorder (MDD) and bipolar disorder (BD).

Methods: We identified neuroimaging studies of abnormal neural activities during emotion regulation in depression. We extracted the peak coordinates and effect sizes of differences in brain activity between patients and healthy controls. Using seed-based d mapping, we conducted voxel-wise meta-analyses of the neural activation pattern differences between the 2 groups across conditions involving emotion regulation and those where emotion regulation was not needed.

Results: We included 33 studies reporting 34 data sets, including 23 involving MDD (571 people with MDD and 578 matched controls) and 11 involving BD (358 people with BD and 369 matched controls). Overall, compared with controls, patients with depression showed hyperactivity in the insula and postcentral gyrus, and hypoactivity in the prefrontal part of the inferior, middle, and superior frontal gyrus, the middle temporal gyrus, and the supplementary motor area. In subgroup analyses, data from patients with MDD and studies focused on decreasing negative emotions or using the emotional strategy of reappraisal reported specific hypoactivity in the middle cerebellar peduncles.

Limitations: Given limited studies involving patients with BD, we were unable to detect the common and distinct abnormalities in neural activation between MDD and BD. We did not conduct any meta-regression analyses because of limited information.

Conclusion: In this meta-analysis, we identified hyperactivity in brain regions associated with emotional experience and hypoactivity in brain regions associated with cognitive control during emotion regulation among patients with depression, relative to healthy controls. These findings could help indicate a target for future interventions aimed at increasing emotion regulation capacity for patients with depression.

抑郁症患者情绪调节过程中的神经活动变化:一项荟萃分析。
背景:据报道,抑郁症患者在情绪调节过程中的神经活动存在缺陷。我们试图进行一项荟萃分析,以全面描述抑郁症患者(包括重度抑郁障碍(MDD)和双相情感障碍(BD)患者)在使用情绪调节策略过程中的神经改变:我们确定了抑郁症患者情绪调节过程中异常神经活动的神经影像学研究。我们提取了患者与健康对照组大脑活动差异的峰值坐标和效应大小。利用基于种子的 d 映射,我们对涉及情绪调节和不需要情绪调节的情况下两组之间的神经激活模式差异进行了体素荟萃分析:我们纳入了 33 项研究,报告了 34 组数据,其中 23 项涉及 MDD(571 名 MDD 患者和 578 名匹配对照),11 项涉及 BD(358 名 BD 患者和 369 名匹配对照)。总体而言,与对照组相比,抑郁症患者在岛叶和中央后回表现出过度活跃,而在额叶下回、中回和上回的前额叶部分、颞中回和辅助运动区则表现出过度活跃。在亚组分析中,来自MDD患者的数据以及侧重于减少负面情绪或使用重新评估的情绪策略的研究报告显示,小脑中段足突的特异性活动低下:由于涉及 BD 患者的研究有限,我们无法检测 MDD 和 BD 神经激活的共同和独特异常。由于信息有限,我们没有进行任何荟萃回归分析:在这项荟萃分析中,我们发现与健康对照组相比,抑郁症患者在情绪调节过程中,与情绪体验相关的脑区活动过度,而与认知控制相关的脑区活动不足。这些发现有助于为今后旨在提高抑郁症患者情绪调节能力的干预措施指明目标。
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来源期刊
CiteScore
6.80
自引率
2.30%
发文量
51
审稿时长
2 months
期刊介绍: The Journal of Psychiatry & Neuroscience publishes papers at the intersection of psychiatry and neuroscience that advance our understanding of the neural mechanisms involved in the etiology and treatment of psychiatric disorders. This includes studies on patients with psychiatric disorders, healthy humans, and experimental animals as well as studies in vitro. Original research articles, including clinical trials with a mechanistic component, and review papers will be considered.
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