MRI-quality and morphometric MRI analysis to identify focal cortical dysplasia: An exploratory study

IF 2.7 3区医学 Q2 CLINICAL NEUROLOGY

Seizure-European Journal of Epilepsy Pub Date : 2024-09-30 DOI:10.1016/j.seizure.2024.09.025

E.N. Zuidhoek , J.N.P. Zwemmer , G.H. Visser , JW. Dankbaar , G. Widman

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引用次数: 0

Abstract

Background

In the pre-surgical evaluation of people with focal epilepsy and a normal MRI, Morphometric Analysis Program v2018 (MAP18) aids in detecting visually inconspicuous focal cortical dysplasia (FCD). We investigated the impact of MRI scans with reduced signal-to-noise ratio (SNR) and spatial resolution (SR) on FCD detection by MAP18, aiming to improve the chances of achieving seizure freedom through epilepsy surgery.

Methods

Thirty MRI scans with the identified lesion using MAP18 radiologically confirmed as FCD by a neuroradiologist, were retrospective analysed. SNR and SR were artificially reduced in ten steps, and their impact on MAP18 outcomes was assessed using multilevel analysis.

Results

There was a significant effect after reducing SR and SNR for z-score and volume of the FCD cluster, the total number of detected clusters, and volume of these clusters. After SNR reduction, there was also a significant effect for z-score of the total number of detected clusters. FCD became undetectable by MAP18 after six steps of SR reduction (voxel size 2.8 × 2.8 × 2.8 mm³) and after two steps of SNR reduction.

Conclusions

This exploratory study suggests that reduced SR and SNR negatively affect FCD detection with MRI post-processing (MAP18). The MAP18 evaluator should screen MRI quality before post-processing, particularly for scans with significant visual noise or voxel sizes of 2.8 × 2.8 × 2.8 mm³ and upwards, as repeating a low-quality MRI scan is less burdensome than the adverse effects of continued seizures due to failure to detect FCD.

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识别局灶性皮质发育不良的 MRI 质量和形态计量 MRI 分析：一项探索性研究。

背景：在对MRI正常的局灶性癫痫患者进行手术前评估时，形态计量分析程序v2018（MAP18）有助于检测视觉上不明显的局灶性皮质发育不良（FCD）。我们研究了信噪比（SNR）和空间分辨率（SR）降低的MRI扫描对MAP18检测FCD的影响，旨在提高通过癫痫手术获得癫痫发作自由的机会：回顾性分析了 30 例磁共振成像扫描，神经放射科医生通过放射学确认了使用 MAP18 发现的病灶为 FCD。采用多层次分析法评估其对 MAP18 结果的影响：结果：降低 SR 和 SNR 后，对 FCD 集群的 Z 值和体积、检测到的集群总数以及这些集群的体积均有明显影响。降低信噪比后，对检测到的集群总数的 z 值也有显著影响。经过六步 SR 缩减（体素大小为 2.8 × 2.8 × 2.8 mm³）和两步 SNR 缩减后，MAP18 无法检测到 FCD：这项探索性研究表明，SR 和 SNR 的降低会对 MRI 后处理（MAP18）的 FCD 检测产生负面影响。MAP18 评估人员应在后处理前对 MRI 质量进行筛查，尤其是对于视觉噪音较大或体素大小为 2.8 × 2.8 × 2.8 mm³ 及以上的扫描，因为重复低质量 MRI 扫描的负担要小于因检测不到 FCD 而导致癫痫持续发作的不良影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seizure-European Journal of Epilepsy 医学-临床神经学

CiteScore

5.60

自引率

6.70%

发文量

231

审稿时长

34 days

期刊介绍： Seizure - European Journal of Epilepsy is an international journal owned by Epilepsy Action (the largest member led epilepsy organisation in the UK). It provides a forum for papers on all topics related to epilepsy and seizure disorders.