Association between Maternal Exposure to Arsenic during Pregnancy and Risk of Preterm Birth: A Systematic Review and Meta-Analysis.

IF 1.3 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Iranian Journal of Public Health Pub Date : 2024-04-01 DOI:10.18502/ijph.v53i4.15553

Yanwen Ding, Yuxin Xu, Xiujuan Tan, Mohammad Alizadeh, Hamzeh Alizadeh

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引用次数: 0

Abstract

Background: Several observational studies have suggested that maternal exposure during pregnancy to arsenic is associated with the risk of preterm birth (PTB); however, available evidence is inconsistent. Therefore, we aimed to explore the relation of maternal exposure to arsenic to PTB risk.

Methods: A comprehensive systematic search was carried out from inception to April 2023 in PubMed and Scopus to retrieve all relevant studies. A pooled odds ratio (OR) with corresponding 95% confidence interval (CI) was employed using a random effects model to test the association.

Results: As a result, 14 eligible studies, with 12,619 participants, were included in the meta-analysis. Overall, the pooled OR of all analyzed studies indicated that higher maternal arsenic exposure is significantly related to the 1.12-fold increased odds of PTB (OR = 1.12, 95% CI = 1.04-1.21), with a remarkable heterogeneity across studies (P = <0.001, I² = 70.9%). This association was found in prospective cohort studies (OR = 1.15, 95% CI = 1.05-1.26), but not in non-cohort studies. In the stratified analysis, the majority of subgroups supported the association of arsenic with PTB.

Conclusion: Maternal exposure to arsenic during pregnancy is directly linked to the odds of PTB. Future studies are suggested to investigate the effectiveness of specific measures to decrease exposure to arsenic in high-risk communities, particularly in pregnant women.

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孕产妇孕期接触砷与早产风险之间的关系：系统回顾与元分析》。

背景：一些观察性研究表明，孕妇在怀孕期间接触砷与早产（PTB）风险有关；然而，现有证据并不一致。因此，我们旨在探讨孕产妇砷暴露与早产风险的关系：方法：我们在 PubMed 和 Scopus 上进行了一次全面的系统性检索，检索时间从开始到 2023 年 4 月，以检索所有相关研究。结果：14 项符合条件的研究中，有 3 项研究的母亲暴露于砒霜，有 1 项研究的母亲暴露于砒霜，有 2 项研究的母亲暴露于砒霜：结果：共有 14 项符合条件的研究被纳入荟萃分析，参与人数达 12619 人。总体而言，所有分析研究的汇总 OR 表明，孕产妇砷暴露量越高，患先天性肺结核的几率增加 1.12 倍（OR = 1.12，95% CI = 1.04-1.21），但各研究之间存在显著的异质性（P = 2 = 70.9%）。在前瞻性队列研究（OR = 1.15，95% CI = 1.05-1.26）中发现了这种关联，但在非队列研究中没有发现。在分层分析中，大多数亚组都支持砷与先天性肺结核的相关性：结论：孕产妇在怀孕期间接触砷与发生先天性脑瘫的几率直接相关。建议今后开展研究，调查在高风险社区减少砷暴露的具体措施的有效性，尤其是对孕妇的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

2.20

自引率

7.10%

发文量

300

审稿时长

3-8 weeks

期刊介绍： Iranian Journal of Public Health has been continuously published since 1971, as the only Journal in all health domains, with wide distribution (including WHO in Geneva and Cairo) in two languages (English and Persian). From 2001 issue, the Journal is published only in English language. During the last 41 years more than 2000 scientific research papers, results of health activities, surveys and services, have been published in this Journal. To meet the increasing demand of respected researchers, as of January 2012, the Journal is published monthly. I wish this will assist to promote the level of global knowledge. The main topics that the Journal would welcome are: Bioethics, Disaster and Health, Entomology, Epidemiology, Health and Environment, Health Economics, Health Services, Immunology, Medical Genetics, Mental Health, Microbiology, Nutrition and Food Safety, Occupational Health, Oral Health. We would be very delighted to receive your Original papers, Review Articles, Short communications, Case reports and Scientific Letters to the Editor on the above mentioned research areas.