Global burden of soil-transmitted helminth infections, 1990-2021.

IF 8.1 1区医学

Infectious Diseases of Poverty Pub Date : 2024-10-24 DOI:10.1186/s40249-024-01238-9

Jin Chen, Yanfeng Gong, Qin Chen, Shizhu Li, Yibiao Zhou

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引用次数: 0

Abstract

Background: Soil-transmitted helminth (STH) infections can cause a significant disease burden. It is estimated that 1.5 billion people worldwide are infected with STHs, primarily in tropical and subtropical regions. This study aimed to assess the distribution of the global burden and trend of STH infections from 1990 to 2021.

Methods: We retrieved data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 on the age-standardized rates (ASRs) of prevalence and disability-adjusted life-years (DALYs) of STH infections for all age groups in 204 countries and territories from 1990 to 2021. The ASRs of prevalence and DALYs by age, gender, and socio-demographic index (SDI) were calculated to quantify the spatial distribution and temporal trend. Spearman correlation analysis was used to examine the relationship between ASR and SDI.

Results: In 2021, there were an estimated 642.72 million cases and 1.38 million DALYs caused by STH infections worldwide. The age-standardized prevalence rate (ASPR) of STH infections was 8429.89 [95% uncertainty interval (UI): 7697.23, 9362.18 ] per 100,000 population globally. The ASPR of STH infections varied across 21 geographic regions in 2021, being mainly prevalent in most African and Latin American locations. The prevalence was higher in the groups of 5-19 years, especially the group of 5-9 years with the ASPR of 16,263 (95% UI: 14,877.06, 18,003.49) and ASR of DALYs of 40.69 (95% UI: 25.98, 60.91) per 100,000. The ASPR of STH infections showed an obvious decreasing trend worldwide (estimated annual percent change = - 4.03, 95% confidence interval: - 4.13, - 3.93) with variations in different species infections during the study years. At the regional level, the ASR of STH infections prevalence (r = - 0.8807, P < 0.0001) and DALYs (r = - 0.9069, P < 0.0001) were negatively correlated with SDI .

Conclusions: STH infections remain a public health problem in 2021, particularly in regions such as the middle parts of Africa and Americas, and in the 5-19 age populations. The reduction in the rate of prevalence and the loss of DALYs are negatively correlated with the increase in SDI. Enhancing political commitment, providing accurate preventive chemotherapy, and advancing techniques for surveillance and mapping systems are essential to achieve the target of ending STH infections as a public health problem by 2030.

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1990-2021 年全球土壤传播蠕虫感染的负担。

背景：土壤传播蠕虫（STH）感染可造成严重的疾病负担。据估计，全球有 15 亿人感染了 STHs，主要集中在热带和亚热带地区。本研究旨在评估 1990 年至 2021 年全球感染性传播疾病的负担分布和趋势：我们从《2021 年全球疾病、伤害和风险因素负担研究》（Global Burden of Diseases, Injuries, and Risk Factors Study 2021）中获取了 1990 年至 2021 年 204 个国家和地区各年龄组感染性传播疾病的年龄标准化感染率（ASR）和残疾调整生命年（DALYs）数据。计算了按年龄、性别和社会人口指数（SDI）划分的流行率和残疾调整生命年的 ASRs，以量化空间分布和时间趋势。斯皮尔曼相关分析用于研究 ASR 与 SDI 之间的关系：2021 年，全球因感染性传播疾病而死亡的病例估计为 6.4272 亿例，残疾调整寿命年数为 138 万年。全球每 10 万人口中的性传播疾病年龄标准化流行率（ASPR）为 8429.89 [95% 不确定区间（UI）：7697.23, 9362.18]。2021 年，21 个地理区域的性传播疾病感染率各不相同，主要流行于大多数非洲和拉丁美洲地区。5-19 岁年龄组的流行率较高，尤其是 5-9 岁年龄组，其 ASPR 为 16,263 (95% UI: 14,877.06, 18,003.49) ，DALYs 的 ASR 为 40.69 (95% UI: 25.98, 60.91)/100,000。在全球范围内，感染性传播疾病的年平均病死率呈明显下降趋势（估计年百分比变化=-4.03，95%置信区间：-4.13，-3.93），但在研究期间，不同物种的感染情况有所不同。在地区层面，性传播疾病感染率的 ASR（r = - 0.8807，P 结论：性传播疾病感染率的 ASR 与地区感染率的 ASR 呈正相关，而地区感染率的 ASR 与地区感染率的 ASR 呈负相关：性传播疾病感染仍然是 2021 年的一个公共卫生问题，尤其是在非洲中部和美洲等地区以及 5-19 岁的人群中。患病率的降低和残疾调整寿命年数的损失与 SDI 的增加呈负相关。加强政治承诺、提供准确的预防性化疗以及提高监测和绘图系统的技术水平，对于实现到 2030 年消除性传播疾病感染这一公共卫生问题的目标至关重要。

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来源期刊

Infectious Diseases of Poverty INFECTIOUS DISEASES-

自引率

1.20%

发文量

368

期刊介绍： Infectious Diseases of Poverty is an open access, peer-reviewed journal that focuses on addressing essential public health questions related to infectious diseases of poverty. The journal covers a wide range of topics including the biology of pathogens and vectors, diagnosis and detection, treatment and case management, epidemiology and modeling, zoonotic hosts and animal reservoirs, control strategies and implementation, new technologies and application. It also considers the transdisciplinary or multisectoral effects on health systems, ecohealth, environmental management, and innovative technology. The journal aims to identify and assess research and information gaps that hinder progress towards new interventions for public health problems in the developing world. Additionally, it provides a platform for discussing these issues to advance research and evidence building for improved public health interventions in poor settings.