Reference Range of Quantitative MRI Metrics Corrected T1 and Liver Fat Content in Children and Young Adults: Pooled Participant Analysis.

IF 2 4区医学 Q2 PEDIATRICS

Children-Basel Pub Date : 2024-10-12 DOI:10.3390/children11101230

Elizabeth Shumbayawonda, Cayden Beyer, Benito de Celis Alonso, Silvia Hidalgo-Tobon, Briceida López-Martínez, Miguel Klunder-Klunder, América Liliana Miranda-Lora, E Louise Thomas, Jimmy D Bell, David J Breen, Kamil Janowski, Maciej Pronicki, Wieslawa Grajkowska, Malgorzata Wozniak, Elzbieta Jurkiewicz, Rajarshi Banerjee, Piotr Socha, Po-Wah So

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引用次数: 0

Abstract

Background: Multiparametric MRI markers of liver health corrected T1 (cT1) and proton density fat fraction (PDFF) have shown utility in the management of various chronic liver diseases. We assessed the normal population reference range of both cT1 and PDFF in healthy child and adult volunteers without any known liver disease.

Methods: A retrospective multi-centre pooled analysis of 102 child and young adult (9.1 years (6-18)) volunteers from three centres: Children's Memorial Health Institute (N = 21), University Hospital Southampton (N = 28) and Hospital Infantil de Mexico (N = 53). Sex and ethnic differences were investigated for both cT1 and PDFF. Age effects were investigated with comparison to a pooled adult cohort from the UK Biobank (N = 500) and CoverScan (N = 71), covering an age range of 21 to 81 years.

Results: cT1 values were normally distributed with a median of 748 ms (IQR: 725-768 ms; 2.5-97.5 percentiles: 683-820 ms). PDFF values followed a normal distribution with a median of 1.7% (IQR: 1.3-1.9%; 2.5-97.5 percentiles: 1-4.4%). There were no significant age and sex differences in cT1 and PDFF between children and young adults. No differences in cT1 and PDFF were found between ethnicities. Age comparisons showed statistically significant, but clinically negligible, cT1 (748 ms vs. 732 ms) and PDFF (2.4% vs. 1.9%) differences between paediatric and adult groups, respectively.

Conclusions: Median healthy cT1 and PDFF reference ranges in children and young adults fall within the reported limits for normal of 800 ms and 5%, respectively.

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儿童和青少年核磁共振成像定量指标校正 T1 和肝脏脂肪含量的参考范围：汇总参与者分析

背景：肝脏健康的多参数 MRI 标记校正 T1（cT1）和质子密度脂肪分数（PDFF）已在各种慢性肝病的治疗中显示出效用。我们评估了没有任何已知肝病的健康儿童和成年志愿者的 cT1 和 PDFF 的正常人群参考范围：方法：对来自三个中心的 102 名儿童和年轻成人（9.1 岁（6-18 岁））志愿者进行回顾性多中心汇总分析：儿童纪念健康研究所（21 人）、南安普顿大学医院（28 人）和墨西哥婴儿医院（53 人）。对 cT1 和 PDFF 的性别和种族差异进行了调查。结果：cT1值呈正态分布，中位数为748毫秒（IQR：725-768毫秒；2.5-97.5百分位数：683-820毫秒）。PDFF 值呈正态分布，中位数为 1.7%（IQR：1.3-1.9%；2.5-97.5 百分位数：1-4.4%）。儿童和青少年在 cT1 和 PDFF 方面没有明显的年龄和性别差异。不同种族之间的 cT1 和 PDFF 没有差异。年龄比较显示，儿童组和成人组之间的 cT1（748 ms 对 732 ms）和 PDFF（2.4% 对 1.9%）差异分别具有统计学意义，但在临床上可以忽略不计：结论：儿童和年轻成人的健康 cT1 和 PDFF 参考范围中位数分别为 800 毫秒和 5%，均在报告的正常范围内。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Children-Basel PEDIATRICS-

CiteScore

2.70

自引率

16.70%

发文量

1735

审稿时长

6 weeks

期刊介绍： Children is an international, open access journal dedicated to a streamlined, yet scientifically rigorous, dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries. The publication focuses on sharing clinical, epidemiological and translational science relevant to children’s health. Moreover, the primary goals of the publication are to highlight under‑represented pediatric disciplines, to emphasize interdisciplinary research and to disseminate advances in knowledge in global child health. In addition to original research, the journal publishes expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in pediatric medicine. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits rapid open access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.