Prediction of Whole Liver Graft Weight Based on Biometric Variables in Paediatric and Adult Liver Donors.

IF 2 4区医学 Q2 PEDIATRICS

Children-Basel Pub Date : 2024-10-16 DOI:10.3390/children11101248

Maria Kuksin, Valeska Bidault Jourdainne, Guillaume Rossignol, Philippe Aegerter, Géraldine Hery, Jean-Paul Teglas, Virginie Fouquet, Sophie Branchereau, Florent Guérin

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引用次数: 0

Abstract

Background/objectives: In paediatric liver transplantation, donor-recipient compatibility depends on graft size. We explored whether the graft weight can be predicted using the donor's biometric parameters.

Methods: We used seven easily available biometric variables in 142 anonymised paediatric and adult donors, with data collected between 2016 and 2022. The whole or partial liver was transplanted in our hospital from these donors. We identified the variables that had the strongest correlation to our response variable: whole liver graft weight.

Results: In child donors, we determined two linear models: using donor weight and height on the one hand and using donor weight and right liver span on the other hand. Both models had a coefficient of determination R² = 0.86 and p-value < 10^-5. We also determined two models in adult donors using donor weight and height (R² = 0.33, p < 10^-4) and donor weight and sternal height (R² = 0.38, p < 10^-4). The models proved valid based on our external dataset of 245 patients from two institutions.

Conclusions: In clinical practise, our models could provide rapidly accessible estimates to determine whole graft dimension compatibility in liver transplantation in children and adults. Determining similar models predicting the left lobe and lateral segment weight could prove invaluable in paediatric transplantation.

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根据生物测量变量预测儿童和成人肝脏捐献者的全肝移植物重量。

背景/目的：在儿科肝移植中，供体与受体的相容性取决于移植物的大小。我们探讨了是否可以通过供体的生物特征参数来预测移植物的重量：我们在 142 名匿名儿科和成人供体中使用了七种易于获得的生物测量变量，数据收集时间为 2016 年至 2022 年。这些供体在我院进行了全肝或部分肝移植。我们确定了与我们的响应变量（全肝移植重量）相关性最强的变量：在儿童捐献者中，我们确定了两个线性模型：一方面使用捐献者体重和身高，另一方面使用捐献者体重和右肝跨度。两个模型的判定系数 R2 = 0.86，P 值均小于 10-5。我们还利用供体体重和身高（R2 = 0.33，p < 10-4）以及供体体重和胸骨高度（R2 = 0.38，p < 10-4）确定了成人供体的两个模型。根据我们的外部数据集（来自两家机构的 245 名患者），这些模型被证明是有效的：结论：在临床实践中，我们的模型可以提供快速可用的估计值，以确定儿童和成人肝移植中整个移植物尺寸的兼容性。确定预测左叶和侧段重量的类似模型在儿科移植中将证明是非常有价值的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Children-Basel PEDIATRICS-

CiteScore

2.70

自引率

16.70%

发文量

1735

审稿时长

6 weeks

期刊介绍： Children is an international, open access journal dedicated to a streamlined, yet scientifically rigorous, dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries. The publication focuses on sharing clinical, epidemiological and translational science relevant to children’s health. Moreover, the primary goals of the publication are to highlight under‑represented pediatric disciplines, to emphasize interdisciplinary research and to disseminate advances in knowledge in global child health. In addition to original research, the journal publishes expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in pediatric medicine. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits rapid open access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.