Salvage Endoscopic Nasopharyngectomy for Recurrent Nasopharyngeal Cancer: an Institutional Experience.

IF 0.7 Q4 OTORHINOLARYNGOLOGY

Turkish Archives of Otorhinolaryngology Pub Date : 2024-10-23 DOI:10.4274/tao.2024.2024-1-2

Ergin Eroğlu, A Erim Pamuk, Serdar Özer, Tevfik Metin Önerci

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Abstract

Objective: This study aims to present the surgical and oncological long-term outcomes of patients with locally recurrent nasopharyngeal cancer (NPC) following endoscopic endonasal nasopharyngectomy (EEN).

Methods: The medical records of 11 patients who underwent EEN due to recurrent NPC were retrospectively reviewed.

Results: The mean age of the patient cohort, consisting of 10 males (90.9%) and one female (9.1%), was 44±13.01 years at the time of initial diagnosis. Seven patients (63.7%) had local recurrence, and four patients (36.3%) had loco-regional recurrence. The mean time to first recurrence from the initial diagnosis was 40.3 months, with a 5-year overall survival (OS) rate of 72.7% and a disease-free survival (DFS) rate of 27.3%. There were no significant differences between the concurrent chemoradiotherapy (CRT) and induction chemotherapy+concurrent CRT treatment groups in terms of DFS and OS as a first-line treatment (p=0.645).

Conclusion: EEN is a viable alternative approach for selected cases of locally recurrent NPC, considering the morbidities associated with re-irradiation.

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鼻咽癌复发的抢救性内窥镜鼻咽切除术：机构经验。

研究目的本研究旨在介绍局部复发性鼻咽癌（NPC）患者在接受内窥镜鼻咽切除术（EEN）后的手术和肿瘤学长期疗效：方法：回顾性审查了11名因鼻咽癌复发而接受鼻内镜鼻咽切除术的患者的病历：结果：患者群中有 10 名男性（90.9%）和 1 名女性（9.1%），初次诊断时的平均年龄为 44±13.01 岁。7名患者（63.7%）局部复发，4名患者（36.3%）局部区域复发。从初诊到首次复发的平均时间为40.3个月，5年总生存（OS）率为72.7%，无病生存（DFS）率为27.3%。作为一线治疗，同期化疗放疗（CRT）组与诱导化疗+同期CRT治疗组在DFS和OS方面无明显差异（P=0.645）：考虑到再次放疗带来的发病率，EEN是局部复发鼻咽癌特定病例的可行替代方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Turkish Archives of Otorhinolaryngology OTORHINOLARYNGOLOGY-

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