Timing Mechanisms for Circadian Seizures.

IF 2.1 Q3 CLINICAL NEUROLOGY
Kristina Slabeva, Maxime O Baud
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引用次数: 0

Abstract

For centuries, epileptic seizures have been noticed to recur with temporal regularity, suggesting that an underlying biological rhythm may play a crucial role in their timing. In this review, we propose to adopt the framework of chronobiology to study the circadian timing of seizures. We first review observations made on seizure timing in patients with epilepsy and animal models of the disorder. We then present the existing chronobiology paradigm to disentangle intertwined circadian and sleep-wake timing mechanisms. In the light of this framework, we review the existing evidence for specific timing mechanisms in specific epilepsy syndromes and highlight that current knowledge is far from sufficient. We propose that individual seizure chronotypes may result from an interplay between independent timing mechanisms. We conclude with a research agenda to help solve the urgency of ticking seizures.

昼夜节律性癫痫发作的时间机制。
几个世纪以来,人们一直注意到癫痫发作具有时间规律性,这表明潜在的生物节律可能在癫痫发作的时间上起着至关重要的作用。在本综述中,我们建议采用时间生物学的框架来研究癫痫发作的昼夜节律。我们首先回顾了在癫痫患者和癫痫动物模型中观察到的癫痫发作时间。然后,我们介绍现有的时间生物学范式,以区分相互交织的昼夜节律和睡眠-觉醒计时机制。根据这一框架,我们回顾了特定癫痫综合征中特定计时机制的现有证据,并强调目前的知识还远远不够。我们提出,个体癫痫发作的时型可能是独立计时机制之间相互作用的结果。最后,我们提出了一个研究议程,以帮助解决 "滴答 "发作的紧迫性。
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来源期刊
Clocks & Sleep
Clocks & Sleep Multiple-
CiteScore
4.40
自引率
0.00%
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0
审稿时长
7 weeks
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