Associations between Sleep Duration and Autonomic Nervous System Regulation in Patients with Probable Alzheimer's Disease: A Cross-Sectional Pilot Study.

IF 2.1 Q3 CLINICAL NEUROLOGY
Chuen-Ru Liu, Chih-Yuan Yang, Dipanshu Sharma, Tun-Hao Chen, Xian-Qing Huang, Tsui-Mei Hung, Terry B J Kuo, Jwo-Huei Jou
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Abstract

In this study, we aimed to investigate the relationships between sleep duration and autonomic nervous system (ANS) regulation. This cross-sectional pilot study included 27 older patients with probable Alzheimer's disease who were hospitalized at a psychiatric center. We measured heart rate variability to assess ANS regulation at night, evaluated dementia severity via the Clinical Dementia Rating scale, and obtained sleep duration data from sleep diaries maintained by psychiatric nurses. The data were analyzed using repeated-measures generalized linear models with age, sex, dementia severity, hypertension status, and medication use (antipsychotics) as covariates. A sleep duration of 6-9 h per night compared to shorter than 6 h was associated with a greater increase in parasympathetic nervous system activity (p = 0.03), and a sleep duration longer than 9 h was associated with a decrease sympathovagal balance (p = 0.02). In addition, we observed an inverted U-shaped association between sleep duration and ANS regulation. In this pilot study, we demonstrated that a sleep duration of 6-9 h per night may be beneficial for ANS regulation; however, the present study involved only a few participants and had some limitations. Additional research with a larger cohort is needed to confirm these findings.

疑似阿尔茨海默病患者睡眠时间与自律神经系统调节之间的关系:一项横断面试点研究。
本研究旨在探讨睡眠时间与自律神经系统(ANS)调节之间的关系。这项横断面试验研究纳入了 27 名在精神病治疗中心住院治疗的老年阿尔茨海默病患者。我们测量了心率变异性以评估夜间自律神经系统的调节情况,通过临床痴呆评定量表评估了痴呆的严重程度,并从精神科护士记录的睡眠日记中获得了睡眠持续时间数据。数据采用重复测量广义线性模型进行分析,并将年龄、性别、痴呆严重程度、高血压状态和药物使用(抗精神病药物)作为协变量。每晚睡眠时间为 6-9 小时与少于 6 小时相比,与副交感神经系统活动的增加有关(p = 0.03),而睡眠时间超过 9 小时与交感摇摆平衡的降低有关(p = 0.02)。此外,我们还观察到睡眠时间与自律神经系统调节之间呈倒 U 型关系。在这项试验性研究中,我们证明了每晚 6-9 小时的睡眠时间可能有利于自律神经系统的调节。要证实这些发现,还需要对更大范围的人群进行更多的研究。
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来源期刊
Clocks & Sleep
Clocks & Sleep Multiple-
CiteScore
4.40
自引率
0.00%
发文量
0
审稿时长
7 weeks
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