Immunoprofile of radiological Chronic Subdural Hematoma subtypes.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-24 DOI:10.1016/j.wneu.2024.10.081

Anders Schack, Thorbjørn Søren Rønn Jensen, Tina Binderup, Kåre Fugleholm

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Abstract

Objective: This study aimed to investigate the immunological profile of Chronic Subdural Hematoma (CSDH) subtypes based on their radiological appearances, with a focus on comparing the membranous CSDH to other subtypes.

Methods: We prospectively analyzed 170 CSDH cases from 138 patients, categorizing them into 'Membranous' and 'Other' subtypes based on computed tomography scans. Samples were collected from the subdural fluid and systemic blood and analyzed for a panel of inflammatory markers. Demographic data, clinical characteristics, and time since trauma were also assessed.

Results: Time since trauma to diagnostic CT was significantly longer for the 'membranous' subtype (p=0.001). 'Membranous' CSDH exhibited a distinct immunoprofile, including lower hemoglobin levels (p=0.0002) and higher concentrations of MMP-9 (p=0.005) and IL-8 (p<0.0001). Additionally, 'Membranous' CSDH showed elevated levels of IP-10, MIG, and uPAR compared to 'Other' subtypes, with significant correlations between IP-10 and MCP-1 (p=0.013), MIG (p=0.002), and uPAR (p=0.006). IL-8 levels also correlated significantly with MCP-1 (p=0.02), suggesting distinct inflammatory pathways in the 'Membranous' subtype CONCLUSIONS: This study demonstrates that CSDH subtypes, particularly the 'Membranous' subtype, possess a distinct immunological profile. These findings provide novel insights into CSDH pathophysiology. The unique inflammatory landscape of 'Membranous' CSDH, marked by elevated MMP-9 and IL-8 levels, may contribute to its chronic nature.

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放射学慢性硬膜下血肿亚型的免疫图谱。

研究目的本研究旨在根据放射学表现调查慢性硬膜下血肿（CSDH）亚型的免疫学特征，重点比较膜性 CSDH 和其他亚型：我们对 138 名患者的 170 个 CSDH 病例进行了前瞻性分析，根据计算机断层扫描结果将其分为 "膜性 "和 "其他 "亚型。我们采集了硬膜下积液和全身血液样本，并对一系列炎症标记物进行了分析。此外，还对人口统计学数据、临床特征和外伤后的时间进行了评估：结果："膜性 "亚型患者从外伤到 CT 诊断的时间明显更长（P=0.001）。膜性 "CSDH表现出独特的免疫特征，包括较低的血红蛋白水平（p=0.0002）、较高浓度的MMP-9（p=0.005）和IL-8（p=0.001）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.