A strong association between Modic changes type 2 and endplate defects at non-fused segments after ACDF.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-24 DOI:10.1016/j.wneu.2024.10.079

Olga Leonova, Evgeniy Baykov, Aleksandr Krutko

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引用次数: 0

Abstract

Purpose: To determine the association between Modic changes (MC) with other MRI parameters and clinical symptoms of cervical degenerative disc disease (DDD).

Methods: A retrospective analysis of data on patients with cervical DDD who underwent single-level anterior cervical discectomy and fusion. Preoperative demographic data (age, sex, surgical data) were collected, cervical MRI parameters (disc degeneration grade, MC and endplate defects, each determined at each cervical level) and clinical data (Numerical pain rating scale (NPRS) neck and arm, the Neck Disability Index (NDI)) were compared to preoperative data.

Results: The study included 121 patients at Visit 1 and 83 patients at Visit 2. The median follow-up duration was 26.5 [18.9; 33.1] months. Patients with MC had more intense NPRS-based neck pain before surgery compared to patients without MC (p=0.001). There were significant changes in MC rate at the C5-C6 levels due to a significant number of new MCs type 1 and MCs type 2 (p=0.002 and p<0.001, respectively). MC type 2 was associated with disc degeneration, endplate defects defects, patients' age and clinical scales (NDI, NPRS) (p<0.05). The endplate defects defect score threshold for predicting MC type 2 at the С3-С7 cervical levels was 5.

Conclusions: The factor predicting MC type 2 at the C3-C7 cervical levels is submaximal damage to the endplate. The MC rate is increased due to MC type 1 and MC type 2. MC types at the cervical levels may not represent consecutive stages of the same process.

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ACDF 术后，Modic 变异 2 型与非融合节段的终板缺损密切相关。

目的：确定颈椎间盘退行性病变（DDD）的莫迪克变化（MC）与其他 MRI 参数和临床症状之间的关联：对接受单层颈椎椎间盘前路切除术和融合术的颈椎退行性病变患者的数据进行回顾性分析。收集术前人口统计学数据（年龄、性别、手术数据）、颈椎磁共振成像参数（椎间盘退变等级、MC和终板缺损，分别在每个颈椎水平测定）以及临床数据（颈部和手臂疼痛评分量表（NPRS）、颈部残疾指数（NDI））与术前数据进行比较：研究结果：121名患者接受了访视1，83名患者接受了访视2。中位随访时间为 26.5 [18.9; 33.1] 个月。与无 MC 的患者相比，有 MC 的患者术前的 NPRS 颈部疼痛更剧烈（P=0.001）。C5-C6水平的MC率有明显变化，原因是新增了大量1型MC和2型MC（P=0.002和P结论：预测颈椎C3-C7水平MC 2型的因素是终板的亚极度损伤。MC1型和MC2型会增加MC率。颈椎水平的 MC 类型可能并不代表同一过程的连续阶段。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.