Association between remnant cholesterol and risk of kidney stones: a case-control study in Chinese adults.

IF 2 2区医学 Q2 UROLOGY & NEPHROLOGY

Urolithiasis Pub Date : 2024-10-24 DOI:10.1007/s00240-024-01651-7

Dawei Wang, Feng Shi, Dingguo Zhang, Hui Wang, Wensun Chen, Zijian Zhou

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引用次数: 0

Abstract

Remnant cholesterol (RC), a key indicator of dyslipidemia, has been validated as a contributing factor to metabolic and cardiovascular diseases, both of which are closely associated with kidney stones (KS). This study aimed to investigate the association between RC and the risk of KS in Chinese adults. A total of 8,576 KS cases (mean age 55.87, 69.37% male) and 137,523 controls (mean age 54.57, 51.62% male) were included in this case-control study. RC was calculated using the formula: RC = TC-HDL-LDL. KS was ascertained with ultrasound by well-trained physicians. Multivariable logistic and restricted cubic spline (RCS) were applied to investigate the relationship between RC and KS. A total of 146,099 subjects (weighted mean age 54.64 years and 52.66% male) were included with mean RC = 0.8 for controls and RC = 0.72 for KS cases (P < 0.001). The multivariable-adjusted OR for KS occurrence across consecutive quartiles was 1.00 (reference), 1.05 (0.98-1.12), 1.15 (1.07-1.22), and 1.44 (1.35-1.53), respectively. Moreover, each standard deviation increment of RC was associated with a 15% (OR:1.15, 95% CI: 1.12-1.19) higher risk of KS occurrence. RCS showed significant and linear dose-response relationships between RC and KS occurrence (P-overall < 0.001, P-nonlinear = 0.270). The positive associations between RC and KS risk persisted in sensitivity analyses, suggesting the robustness of the results. In this case-control study of Chinese adults, elevated RC was associated with the occurrence of KS.

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残余胆固醇与肾结石风险之间的关系：一项针对中国成年人的病例对照研究。

残余胆固醇（RC）是血脂异常的一个重要指标，已被证实是导致代谢性疾病和心血管疾病的一个因素，而这两种疾病都与肾结石（KS）密切相关。本研究旨在调查中国成年人的 RC 与 KS 风险之间的关系。这项病例对照研究共纳入了 8,576 例 KS 病例（平均年龄 55.87 岁，69.37% 为男性）和 137,523 例对照组（平均年龄 54.57 岁，51.62% 为男性）。RC 的计算公式为RC = TC-HDL-LDL。KS由训练有素的医生通过超声波确定。应用多变量逻辑和限制性立方样条曲线（RCS）研究 RC 和 KS 之间的关系。共纳入了 146 099 名受试者（加权平均年龄为 54.64 岁，52.66% 为男性），对照组的平均 RC = 0.8，KS 病例的平均 RC = 0.72（P＜0.05）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Urolithiasis UROLOGY & NEPHROLOGY-

CiteScore

4.50

自引率

6.50%

发文量

期刊介绍： Official Journal of the International Urolithiasis Society The journal aims to publish original articles in the fields of clinical and experimental investigation only within the sphere of urolithiasis and its related areas of research. The journal covers all aspects of urolithiasis research including the diagnosis, epidemiology, pathogenesis, genetics, clinical biochemistry, open and non-invasive surgical intervention, nephrological investigation, chemistry and prophylaxis of the disorder. The Editor welcomes contributions on topics of interest to urologists, nephrologists, radiologists, clinical biochemists, epidemiologists, nutritionists, basic scientists and nurses working in that field. Contributions may be submitted as full-length articles or as rapid communications in the form of Letters to the Editor. Articles should be original and should contain important new findings from carefully conducted studies designed to produce statistically significant data. Please note that we no longer publish articles classified as Case Reports. Editorials and review articles may be published by invitation from the Editorial Board. All submissions are peer-reviewed. Through an electronic system for the submission and review of manuscripts, the Editor and Associate Editors aim to make publication accessible as quickly as possible to a large number of readers throughout the world.