Relationship Between Perfluoroalkyl Acids in Human Serum and Sjogren's Syndrome: A Case-Control Study of Populations in Hangzhou, China.

IF 3.9 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Toxics Pub Date : 2024-10-21 DOI:10.3390/toxics12100764

Yun Zhao, Shetuan Hu, Hangbiao Jin, Chuanbing Fan, Kaizhen Liao, Songzhao Zhang, Jing Xue

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Abstract

Exposure to perfluoroalkyl acids (PFAAs) has been found to elicit a range of detrimental effects on human health. However, limited research has investigated the impact of PFAAs on immunity and immune disorders such as Sjogren's syndrome, with existing studies yielding inconsistent results. This study was conducted in Hangzhou, China, with an initial cohort comprising 156 healthy individuals and 162 patients diagnosed with Sjogren's syndrome. We quantified serum levels of PFAAs and examined associations between PFAAs and both susceptibilities to the development of Sjogren's syndrome and immune marker concentrations. Nine PFAAs were frequently detected in the serum, with perfluorooctanoate (PFOA) exhibiting the highest concentration, followed by perfluorooctanesulfonate (PFOS). Exposure to PFOA and perfluorotridecanoate (PFTrDA) was inversely associated with the disease. Furthermore, a negative correlation between PFOA and C-reactive protein (CRP) was observed. These findings suggest that exposure to specific PFAAs may impact the immune system and potentially influence the development of Sjogren's syndrome.

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人体血清中的全氟烷基酸与 Sjogren's 综合征的关系：中国杭州人群的病例对照研究。

研究发现，接触全氟烷基酸（PFAAs）会对人体健康产生一系列有害影响。然而，有关全氟烷基酸对免疫和免疫失调（如斯约格伦综合症）的影响的研究还很有限，现有研究得出的结果也不一致。本研究在中国杭州进行，最初的研究对象包括 156 名健康人和 162 名确诊为 Sjogren's 综合征的患者。我们对血清中的 PFAAs 水平进行了量化，并研究了 PFAAs 与 Sjogren's 综合征易感性和免疫标志物浓度之间的关系。血清中经常检测到九种全氟辛烷磺酸，其中全氟辛酸（PFOA）浓度最高，其次是全氟辛烷磺酸（PFOS）。全氟辛酸和全氟十三酸的暴露与疾病成反比。此外，还观察到全氟辛烷磺酸与 C 反应蛋白（CRP）呈负相关。这些研究结果表明，接触特定的全氟辛酸可能会影响免疫系统，并有可能影响斯约格伦综合征的发病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxics Chemical Engineering-Chemical Health and Safety

CiteScore

4.50

自引率

10.90%

发文量

681

审稿时长

6 weeks

期刊介绍： The Journal accepts papers describing work that furthers our understanding of the exposure, effects, and risks of chemicals and materials in humans and the natural environment as well as approaches to assess and/or manage the toxicological and ecotoxicological risks of chemicals and materials. The journal covers a wide range of toxic substances, including metals, pesticides, pharmaceuticals, biocides, nanomaterials, and polymers such as micro- and mesoplastics. Toxics accepts papers covering: The occurrence, transport, and fate of chemicals and materials in different systems (e.g., food, air, water, soil); Exposure of humans and the environment to toxic chemicals and materials as well as modelling and experimental approaches for characterizing the exposure in, e.g., water, air, soil, food, and consumer products; Uptake, metabolism, and effects of chemicals and materials in a wide range of systems including in-vitro toxicological assays, aquatic and terrestrial organisms and ecosystems, model mammalian systems, and humans; Approaches to assess the risks of chemicals and materials to humans and the environment; Methodologies to eliminate or reduce the exposure of humans and the environment to toxic chemicals and materials.