Comprehensive insights into glioblastoma multiforme: drug delivery challenges and multimodal treatment strategies.

IF 3 Q2 PHARMACOLOGY & PHARMACY
Ashish Dhiman, Dhwani Rana, Derajram Benival, Kalpna Garkhal
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引用次数: 0

Abstract

Glioblastoma multiforme (GBM) is one of the most common and malignant brain tumors, with a high prevalence in elderly population. Most chemotherapeutic agents fail to reach the tumor site due to various challenges. However, smart nanocarriers have demonstrated excellent drug-loading capabilities, enabling them to cross the blood brain tumor barrier for the GBM treatment. Surface modification of nanocarriers has significantly enhanced their potential for targeting therapeutics. Moreover, recent innovations in drug therapies, such as the incorporation of theranostic agents in nanocarriers and antibody-drug conjugates, have offered newer insights for both diagnosis and treatment. This review focuses on recent advances in new therapeutic interventions for GBM, with an emphasis on the nanotheranostics systems to maximize therapeutic and diagnostic outcomes.

全面了解多形性胶质母细胞瘤:给药挑战和多模式治疗策略。
多形性胶质母细胞瘤(GBM)是最常见的恶性脑肿瘤之一,在老年人群中发病率很高。由于面临各种挑战,大多数化疗药物都无法到达肿瘤部位。然而,智能纳米载体已显示出卓越的药物负载能力,使其能够穿过血脑屏障,用于治疗脑胶质瘤。纳米载体的表面改性大大提高了其靶向治疗的潜力。此外,药物疗法的最新创新,如在纳米载体和抗体药物共轭物中加入治疗药物,为诊断和治疗提供了新的思路。本综述将重点介绍 GBM 新疗法干预措施的最新进展,并着重介绍可最大限度提高治疗和诊断效果的纳米治疗系统。
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来源期刊
Therapeutic delivery
Therapeutic delivery PHARMACOLOGY & PHARMACY-
CiteScore
5.50
自引率
0.00%
发文量
25
期刊介绍: Delivering therapeutics in a way that is right for the patient - safe, painless, reliable, targeted, efficient and cost effective - is the fundamental aim of scientists working in this area. Correspondingly, this evolving field has already yielded a diversity of delivery methods, including injectors, controlled release formulations, drug eluting implants and transdermal patches. Rapid technological advances and the desire to improve the efficacy and safety profile of existing medications by specific targeting to the site of action, combined with the drive to improve patient compliance, continue to fuel rapid research progress. Furthermore, the emergence of cell-based therapeutics and biopharmaceuticals such as proteins, peptides and nucleotides presents scientists with new and exciting challenges for the application of therapeutic delivery science and technology. Successful delivery strategies increasingly rely upon collaboration across a diversity of fields, including biology, chemistry, pharmacology, nanotechnology, physiology, materials science and engineering. Therapeutic Delivery recognizes the importance of this diverse research platform and encourages the publication of articles that reflect the highly interdisciplinary nature of the field. In a highly competitive industry, Therapeutic Delivery provides the busy researcher with a forum for the rapid publication of original research and critical reviews of all the latest relevant and significant developments, and focuses on how the technological, pharmacological, clinical and physiological aspects come together to successfully deliver modern therapeutics to patients. The journal delivers this essential information in concise, at-a-glance article formats that are readily accessible to the full spectrum of therapeutic delivery researchers.
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