Evaluation of preoperative intraperitoneal injection of bupivacaine for intraoperative antinociception in cats undergoing ovariohysterectomy: A randomized clinical trial

IF 2.2 3区农林科学 Q1 VETERINARY SCIENCES

Research in veterinary science Pub Date : 2024-10-16 DOI:10.1016/j.rvsc.2024.105439

Brandon M. Lawler, Alonso G.P. Guedes, Caitlin C. Tearney, Lauren Ienello, Brian Walters, Adrienne L. Haley, Erin Wendt-Hornickle

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引用次数: 0

Abstract

Objective

To determine if preoperative intraperitoneal bupivacaine can minimize intra- and postoperative nociception/pain in cats undergoing ovariohysterectomy.

Study design

Prospective, randomized, investigator-blinded, placebo-controlled clinical trial.

Animals

Forty-seven, intact female cats.

Methods

Cats were anesthetized using a standard protocol and randomized to receive ultrasound-guided intraperitoneal 0.9 % saline (US-S) or 0.25 % bupivacaine (US-IPLA) before ovariohysterectomy. On recovery, US-S cats received 2 mg/kg robenacoxib subcutaneously and US-IPLA cats received equivalent volume of 0.9 % saline subcutaneously. Intraoperative outcome variables included heart rate (HR), respiratory rate (fR), systolic arterial pressure (SAP), and vaporizer setting associated with relevant surgical events characterized by manipulation of each ovarian pedicle (OP1, OP2) and the uterine body (UB). The postoperative outcome variable was need for rescue analgesia, determined using the Glasgow Composite Measure Pain Scale during 6 h after tracheal extubation. Intraoperative data were analyzed using two-way ANOVA and Šidák's multiple comparisons test. The probability of postoperative rescue analgesia was analyzed using the Gehan–Breslow–Wilcoxon test. Significance was p < 0.05.

Results

Compared to baseline, all surgical events caused significant increases in HR and SAP in both groups, fR increased in US-IPLA but not in US-S, vaporizer settings remained unchanged during OP1, OP2 and UB in group US-IPLA, and were significantly higher only during OP1 in group US-S. There were no significant between-group differences in intraoperative variables and postoperative need for rescue analgesia.

Conclusions and clinical relevance

Preoperative intraperitoneal bupivacaine had minimal effects on intraoperative indicators of nociception. The need for rescue analgesia was not significantly different between groups.

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对接受卵巢切除术的猫术前腹腔注射布比卡因以进行术中镇痛的评估：随机临床试验。

研究目的确定术前腹腔注射布比卡因能否最大程度地减轻接受卵巢切除术的猫术中和术后的痛觉/疼痛：前瞻性、随机、研究者盲法、安慰剂对照临床试验：47只完好无损的雌性猫：方法：采用标准方案对猫进行麻醉，并在卵巢切除术前随机接受超声引导下腹腔注射 0.9 % 生理盐水（US-S）或 0.25 % 布比卡因（US-IPLA）。恢复时，US-S 猫皮下注射 2 mg/kg 罗苯昔布，US-IPLA 猫皮下注射等量的 0.9 % 生理盐水。术中结果变量包括心率（HR）、呼吸频率（fR）、收缩动脉压（SAP）和与相关手术事件相关的蒸发器设置，这些手术事件的特点是操作每个卵巢蒂（OP1、OP2）和子宫体（UB）。术后结果变量为气管拔管后 6 小时内是否需要镇痛抢救，采用格拉斯哥综合疼痛量表确定。术中数据采用双向方差分析和希达克多重比较检验进行分析。使用 Gehan-Breslow-Wilcoxon 检验分析了术后抢救性镇痛的概率。结果以 p 表示显著性：与基线相比，两组所有手术事件均导致 HR 和 SAP 显著升高，US-IPLA 组 fR 升高，US-S 组不升高，US-IPLA 组在 OP1、OP2 和 UB 期间蒸发器设置保持不变，US-S 组仅在 OP1 期间显著升高。术中变量和术后镇痛抢救需求在组间无明显差异：结论和临床意义：术前腹腔注射布比卡因对术中痛觉指标的影响极小。术前腹腔注射布比卡因对术中痛觉指标的影响微乎其微，各组间对镇痛抢救的需求也无明显差异。

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来源期刊

Research in veterinary science 农林科学-兽医学

CiteScore

4.40

自引率

4.20%

发文量

312

审稿时长

75 days

期刊介绍： Research in Veterinary Science is an International multi-disciplinary journal publishing original articles, reviews and short communications of a high scientific and ethical standard in all aspects of veterinary and biomedical research. The primary aim of the journal is to inform veterinary and biomedical scientists of significant advances in veterinary and related research through prompt publication and dissemination. Secondly, the journal aims to provide a general multi-disciplinary forum for discussion and debate of news and issues concerning veterinary science. Thirdly, to promote the dissemination of knowledge to a broader range of professions, globally. High quality papers on all species of animals are considered, particularly those considered to be of high scientific importance and originality, and with interdisciplinary interest. The journal encourages papers providing results that have clear implications for understanding disease pathogenesis and for the development of control measures or treatments, as well as those dealing with a comparative biomedical approach, which represents a substantial improvement to animal and human health. Studies without a robust scientific hypothesis or that are preliminary, or of weak originality, as well as negative results, are not appropriate for the journal. Furthermore, observational approaches, case studies or field reports lacking an advancement in general knowledge do not fall within the scope of the journal.