Online unsupervised performance-based cognitive testing: A feasible and reliable approach to scalable cognitive phenotyping of Parkinson's patients

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders Pub Date : 2024-10-22 DOI:10.1016/j.parkreldis.2024.107183

Nasri Balit, Sophie Sun, Yilin Zhang, Madeleine Sharp

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引用次数: 0

Abstract

Introduction

A better understanding of the heterogeneity in the cognitive and mood symptoms of Parkinson's disease will require research conducted in large samples of patients. Fully online and remote research assessments present interesting opportunities for scaling up research but the feasibility and reliability of remote and fully unsupervised performance-based cognitive testing in individuals with Parkinson's disease is unknown. This study aims to establish the feasibility and reliability of this testing modality in Parkinson's patients.

Methods

Sixty-seven Parkinson's patients and 36 older adults completed two sessions of an at-home, online battery of five cognitive tasks and three self-report questionnaires. Feasibility was established by examining completion rates and data quality. Test-retest reliability was evaluated using the Intraclass Correlation Coefficient (ICC (2,1)).

Results

Overall completion rates and data quality were high with few participant exclusions across tasks. With regards to test-retest reliability, intraclass correlation coefficients were quite variable across measures extracted from a task as well as across tasks, but at least one standard measure from each task achieved moderate to good reliability levels. Self-report questionnaires achieved a higher test-retest reliability than cognitive tasks. Feasibility and reliability were similar between Parkinson's patients and older adults.

Conclusion

These results demonstrate that remote and unsupervised testing is a feasible and reliable method of measuring cognition and mood in Parkinson's patients that achieves levels of test-retest reliability that are comparable to those reported for standard in-person testing.

查看原文本刊更多论文

基于表现的在线无监督认知测试：对帕金森病人进行可扩展认知表型的可行且可靠的方法。

导言：要更好地了解帕金森病认知和情绪症状的异质性，需要对大量患者样本进行研究。完全在线和远程研究评估为扩大研究规模提供了有趣的机会，但在帕金森病患者中进行基于表现的远程和完全无监督认知测试的可行性和可靠性尚不清楚。本研究旨在确定这种测试模式在帕金森病患者中的可行性和可靠性：67 名帕金森病患者和 36 名老年人完成了两次在家进行的在线认知测试，包括五项认知任务和三份自我报告问卷。通过检查完成率和数据质量来确定可行性。使用类内相关系数（ICC (2,1)）评估了重测可靠性：结果：总体完成率和数据质量都很高，各项任务中很少有参与者被排除在外。在测试-再测试可靠性方面，从一项任务中提取的不同测量指标之间以及不同任务之间的类内相关系数差异很大，但每项任务中至少有一项标准测量指标达到了中等至良好的可靠性水平。与认知任务相比，自我报告问卷的测试再测可靠性更高。帕金森病人和老年人的可行性和可靠性相似：这些结果表明，远程和无监督测试是测量帕金森病人认知和情绪的一种可行且可靠的方法，其测试-再测可靠性水平与所报道的标准现场测试的可靠性水平相当。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Parkinsonism & related disorders 医学-临床神经学

CiteScore

6.20

自引率

4.90%

发文量

292

审稿时长

39 days

期刊介绍： Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.