Non-coding RNAs: Key regulators of CDK and Wnt/β-catenin signaling in cancer

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2024-10-15 DOI:10.1016/j.prp.2024.155659

Mohammad Arshad Javed Shaikh , M.Arockia Babu , Nehmat Ghaboura , Abdulmalik S.A. Altamimi , Pawan Sharma , Richa Rani , G.B. Rani , Sorabh Lakhanpal , Haider Ali , Ashok Kumar Balaraman , Sushama Rawat , Sami I. Alzarea , Imran Kazmi

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引用次数: 0

Abstract

Non-coding RNAs (ncRNAs) have become important modulators of gene expression and biological processes, contributing significantly to the initiation and spread of cancer. This study focuses on the complex interactions between ncRNAs and two major signaling pathways—Wnt/β-catenin signaling and cyclin-dependent kinase (CDK)—linked to cancer. We provide an overview of current research on the modulation of these pathways in many cancer types by distinct classes of ncRNAs, such as miRNAs, lncRNAs, and circRNAs. The review focuses on the processes by which ncRNAs regulate cancer cell survival, proliferation, and metastasis. These mechanical processes include CDK activity, the activation of the Wnt/β-catenin cascade and cell cycle advancement. We also discuss the importance of ncRNAs in drug resistance and treatment outcomes, as well as prognosis markers (diagnostic) and therapeutic targets for cancer. Understanding these complex regulatory networks may help in a large way to improve cancer research and diagnosis - but also perhaps treat patients more effectively.

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非编码 RNA：癌症中 CDK 和 Wnt/β-catenin 信号转导的关键调节因子

非编码 RNA（ncRNA）已成为基因表达和生物过程的重要调节因子，对癌症的发生和扩散起着重要作用。本研究的重点是 ncRNA 与与癌症相关的两大信号通路--Wnt/β-catenin 信号通路和细胞周期蛋白依赖性激酶 (CDK) 之间复杂的相互作用。我们概述了目前关于不同类别的 ncRNA（如 miRNA、lncRNA 和 circRNA）在许多癌症类型中调节这些通路的研究。综述的重点是 ncRNA 调节癌细胞存活、增殖和转移的过程。这些机械过程包括 CDK 活性、Wnt/β-catenin 级联的激活和细胞周期的推进。我们还讨论了 ncRNA 在耐药性和治疗结果中的重要性，以及作为癌症预后标志物（诊断）和治疗靶点的重要性。了解这些复杂的调控网络可能会在很大程度上有助于提高癌症研究和诊断水平，同时也能更有效地治疗患者。

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.