Artificial Intelligence (AI) Applications in Drug Discovery and Drug Delivery: Revolutionizing Personalized Medicine.

IF 4.9 3区 医学 Q1 PHARMACOLOGY & PHARMACY
Dolores R Serrano, Francis C Luciano, Brayan J Anaya, Baris Ongoren, Aytug Kara, Gracia Molina, Bianca I Ramirez, Sergio A Sánchez-Guirales, Jesus A Simon, Greta Tomietto, Chrysi Rapti, Helga K Ruiz, Satyavati Rawat, Dinesh Kumar, Aikaterini Lalatsa
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引用次数: 0

Abstract

Artificial intelligence (AI) encompasses a broad spectrum of techniques that have been utilized by pharmaceutical companies for decades, including machine learning, deep learning, and other advanced computational methods. These innovations have unlocked unprecedented opportunities for the acceleration of drug discovery and delivery, the optimization of treatment regimens, and the improvement of patient outcomes. AI is swiftly transforming the pharmaceutical industry, revolutionizing everything from drug development and discovery to personalized medicine, including target identification and validation, selection of excipients, prediction of the synthetic route, supply chain optimization, monitoring during continuous manufacturing processes, or predictive maintenance, among others. While the integration of AI promises to enhance efficiency, reduce costs, and improve both medicines and patient health, it also raises important questions from a regulatory point of view. In this review article, we will present a comprehensive overview of AI's applications in the pharmaceutical industry, covering areas such as drug discovery, target optimization, personalized medicine, drug safety, and more. By analyzing current research trends and case studies, we aim to shed light on AI's transformative impact on the pharmaceutical industry and its broader implications for healthcare.

人工智能(AI)在药物发现和给药中的应用:革新个性化医疗。
人工智能(AI)涵盖了制药公司几十年来一直在使用的各种技术,包括机器学习、深度学习和其他先进的计算方法。这些创新为加速药物发现和交付、优化治疗方案和改善患者疗效带来了前所未有的机遇。人工智能正在迅速改变制药行业,彻底改变从药物开发和发现到个性化医疗的方方面面,包括靶点识别和验证、辅料选择、合成路线预测、供应链优化、连续生产过程监控或预测性维护等。虽然人工智能的整合有望提高效率、降低成本、改善药品和患者健康,但从监管角度来看,它也提出了一些重要问题。在这篇综述文章中,我们将全面介绍人工智能在制药行业的应用,涵盖药物发现、靶点优化、个性化医疗、药物安全等领域。通过分析当前的研究趋势和案例研究,我们旨在阐明人工智能对制药业的变革性影响及其对医疗保健的广泛意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pharmaceutics
Pharmaceutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
7.90
自引率
11.10%
发文量
2379
审稿时长
16.41 days
期刊介绍: Pharmaceutics (ISSN 1999-4923) is an open access journal which provides an advanced forum for the science and technology of pharmaceutics and biopharmaceutics. It publishes reviews, regular research papers, communications,  and short notes. Covered topics include pharmacokinetics, toxicokinetics, pharmacodynamics, pharmacogenetics and pharmacogenomics, and pharmaceutical formulation. Our aim is to encourage scientists to publish their experimental and theoretical details in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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