Capparis sepiaria-Loaded Sodium Alginate Single- and Double-Layer Membrane Composites for Wound Healing.

IF 4.9 3区医学 Q1 PHARMACOLOGY & PHARMACY

Pharmaceutics Pub Date : 2024-10-10 DOI:10.3390/pharmaceutics16101313

Sindi P Ndlovu, Keolebogile S C M Motaung, Mapula Razwinani, Sibusiso Alven, Samson A Adeyemi, Philemon N Ubanako, Lindokuhle M Ngema, Thierry Y Fonkui, Derek T Ndinteh, Pradeep Kumar, Yahya E Choonara, Blessing A Aderibigbe

{"title":"Capparis sepiaria-Loaded Sodium Alginate Single- and Double-Layer Membrane Composites for Wound Healing.","authors":"Sindi P Ndlovu, Keolebogile S C M Motaung, Mapula Razwinani, Sibusiso Alven, Samson A Adeyemi, Philemon N Ubanako, Lindokuhle M Ngema, Thierry Y Fonkui, Derek T Ndinteh, Pradeep Kumar, Yahya E Choonara, Blessing A Aderibigbe","doi":"10.3390/pharmaceutics16101313","DOIUrl":null,"url":null,"abstract":"Background: Effective wound dressing is the key solution to combating the increased death rate and prolonged hospital stay common to patients with wounds. Methods: Sodium alginate-based single- and double-layer membranes incorporated with Capparis sepiaria root extract were designed using the solvent-casting method from a combination of polyvinyl alcohol (PVA), Pluronic F127 (PF127), and gum acacia. Results: The successful preparation of the membranes and loading of the extract were confirmed using Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The prepared membranes were biodegradable and non-toxic to human skin cells (HaCaT), with high biocompatibility of 92 to 112% cell viability and good hemocompatibility with absorbance ranging from 0.17 to 0.30. The membrane's highest water vapor transmission rate was 1654.7333 ± 0.736 g/m2/day and the highest % porosity was 76%. The membranes supported cellular adhesion and migration, with the highest closure being 68% after 4 days compared with the commercial wound dressings. This membrane exhibited enhanced antimicrobial activity against the pathogens responsible for wound infections. Conclusions: The distinct features of the membranes make them promising wound dressings for treating infected wounds.","PeriodicalId":19894,"journal":{"name":"Pharmaceutics","volume":"16 10","pages":""},"PeriodicalIF":4.9000,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510319/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/pharmaceutics16101313","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Effective wound dressing is the key solution to combating the increased death rate and prolonged hospital stay common to patients with wounds. Methods: Sodium alginate-based single- and double-layer membranes incorporated with Capparis sepiaria root extract were designed using the solvent-casting method from a combination of polyvinyl alcohol (PVA), Pluronic F127 (PF127), and gum acacia. Results: The successful preparation of the membranes and loading of the extract were confirmed using Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The prepared membranes were biodegradable and non-toxic to human skin cells (HaCaT), with high biocompatibility of 92 to 112% cell viability and good hemocompatibility with absorbance ranging from 0.17 to 0.30. The membrane's highest water vapor transmission rate was 1654.7333 ± 0.736 g/m²/day and the highest % porosity was 76%. The membranes supported cellular adhesion and migration, with the highest closure being 68% after 4 days compared with the commercial wound dressings. This membrane exhibited enhanced antimicrobial activity against the pathogens responsible for wound infections. Conclusions: The distinct features of the membranes make them promising wound dressings for treating infected wounds.

查看原文本刊更多论文

用于伤口愈合的藻酸钠单层和双层膜复合材料（Capparis sepiaria-Loaded Sodium Alginate Single- and Double-Layer Membrane Composites）。

背景：有效的伤口敷料是解决伤口患者死亡率上升和住院时间延长问题的关键。方法：在藻酸钠单层和双层膜中加入卡帕瑞藻提取物：采用溶剂浇注法设计了掺有蓝花楹根提取物的海藻酸钠基单层和双层膜，该膜由聚乙烯醇 (PVA)、Pluronic F127 (PF127) 和阿拉伯树胶组合而成。结果傅立叶变换红外光谱（FTIR）和 X 射线衍射（XRD）证实了膜的成功制备和提取物的负载。制备的膜可生物降解，对人类皮肤细胞（HaCaT）无毒，具有较高的生物相容性，细胞存活率为 92% 至 112%，并具有良好的血液相容性，吸光度在 0.17 至 0.30 之间。膜的最高水蒸气透过率为 1654.7333 ± 0.736 克/平方米/天，最高孔隙率为 76%。该膜支持细胞粘附和迁移，与商用伤口敷料相比，4 天后最高闭合率为 68%。这种膜对造成伤口感染的病原体具有更强的抗菌活性。结论这种膜的显著特点使其成为治疗感染伤口的有前途的伤口敷料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Pharmaceutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

7.90

自引率

11.10%

发文量

2379

审稿时长

16.41 days

期刊介绍： Pharmaceutics (ISSN 1999-4923) is an open access journal which provides an advanced forum for the science and technology of pharmaceutics and biopharmaceutics. It publishes reviews, regular research papers, communications, and short notes. Covered topics include pharmacokinetics, toxicokinetics, pharmacodynamics, pharmacogenetics and pharmacogenomics, and pharmaceutical formulation. Our aim is to encourage scientists to publish their experimental and theoretical details in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.