Chromatography and Spectroscopic Technique-Based Rapid Characterization of Nano-Carrier Pharmaceuticals.

Q2 Pharmacology, Toxicology and Pharmaceutics

Pharmaceutical nanotechnology Pub Date : 2024-10-21 DOI:10.2174/0122117385319695240911115239

Shamim, Tarmeen Ali

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引用次数: 0

Abstract

A nanocarrier is a novel colloidal system whose particle size ranges between 1-100 nm. It is extensively utilized in drug delivery and various other sectors, such as the pharmaceutical, food, and dairy industries. The nanocarrier systems, including solid lipid nanoparticles, micelles, liposomes, and other encapsulated compounds, have improved stability, solubility, bioavailability, and quality. Nanocarriers offer therapeutic effectiveness with low toxicity because of their biocompatibility and ability to cross body barriers. Various analytical techniques, such as chromatography and spectroscopy, are crucial in qualitative and quantitative analysis of nanocarrier-based formulations. Molecular identification and drug content determination require chromatographic techniques, particularly HPLC. Spectroscopic techniques such as LC-MS, NMR, GC-MS, CE-MS, Raman, and IR are used to analyze the interaction and molecular structure of the sample. Nanocarriers have several benefits but face various challenges like stability, drug loading, regulatory standards, and biocompatibility. Future surface engineering and nanocarrier design advancements could improve targeted drug delivery and sustained diagnostic applications, significantly impacting healthcare.

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基于色谱和光谱技术的纳米载体药物快速表征。

纳米载体是一种新型胶体系统，其粒径在 1-100 纳米之间。它被广泛应用于药物输送和其他各个领域，如制药、食品和乳制品行业。纳米载体系统，包括固体脂质纳米颗粒、胶束、脂质体和其他封装化合物，具有更好的稳定性、溶解性、生物利用度和质量。纳米载体具有生物相容性和穿越人体屏障的能力，因此治疗效果好，毒性低。色谱法和光谱法等各种分析技术对纳米载体制剂的定性和定量分析至关重要。分子鉴定和药物含量测定需要色谱技术，尤其是 HPLC。光谱技术，如 LC-MS、NMR、GC-MS、CE-MS、拉曼和红外光谱，可用于分析样品的相互作用和分子结构。纳米载体具有多种优点，但也面临着稳定性、药物负载、监管标准和生物相容性等各种挑战。未来表面工程和纳米载体设计的进步可以改善靶向给药和持续诊断应用，对医疗保健产生重大影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutical nanotechnology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.20

自引率

0.00%

发文量

期刊介绍： Pharmaceutical Nanotechnology publishes original manuscripts, full-length/mini reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterisation and pharmaceutical (or diagnostic) application of materials at the nanoscale. The nanoscale is defined as a size range of below 1 µm. Scientific findings related to micro and macro systems with functionality residing within features defined at the nanoscale are also within the scope of the journal. Manuscripts detailing the synthesis, exhaustive characterisation, biological evaluation, clinical testing and/ or toxicological assessment of nanomaterials are of particular interest to the journal’s readership. Articles should be self contained, centred around a well founded hypothesis and should aim to showcase the pharmaceutical/ diagnostic implications of the nanotechnology approach. Manuscripts should aim, wherever possible, to demonstrate the in vivo impact of any nanotechnological intervention. As reducing a material to the nanoscale is capable of fundamentally altering the material’s properties, the journal’s readership is particularly interested in new characterisation techniques and the advanced properties that originate from this size reduction. Both bottom up and top down approaches to the realisation of nanomaterials lie within the scope of the journal.