Perceptual and semantic deficits in face recognition in semantic dementia

IF 2 3区心理学 Q3 BEHAVIORAL SCIENCES

Neuropsychologia Pub Date : 2024-10-22 DOI:10.1016/j.neuropsychologia.2024.109020

Golnaz Yadollahikhales , Maria Luisa Mandelli , Zoe Ezzes , Janhavi Pillai , Buddhika Ratnasiri , David Paul Baquirin , Zachary Miller , Jessica de Leon , Boon Lead Tee , William Seeley , Howard Rosen , Bruce Miller , Joel Kramer , Virginia Sturm , Maria Luisa Gorno-Tempini , Maxime Montembeault

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Abstract

State of the art

Semantic dementia (SD) patients including semantic variant primary progressive aphasia (svPPA) and semantic behavioral variant frontotemporal dementia (sbvFTD) patients show semantic difficulties identifying faces and known people related to right anterior temporal lobe (ATL) atrophy. However, it remains unclear whether they also have perceptual deficits in face recognition.

Methodology

We selected 74 SD patients (54 with svPPA and predominant left ATL atrophy and 20 with sbvFTD and predominant right ATL atrophy) and 36 cognitively healthy controls (HC) from UCSF Memory and Aging Center. They underwent a perceptual face processing test (Benton facial recognition test-short version; BFRT-S), and semantic face processing tests (UCSF Famous people battery – Recognition, Naming, Semantic associations – pictures and words subtests), as well as structural magnetic resonance imaging (MRI). Neural correlates with the task's performance were conducted with a Voxel-based morphometry approach using CAT12.

Results

svPPA and sbvFTD patients were impaired on all semantic face processing tests, with sbvFTD patients performing significantly lower on the famous faces’ recognition task in comparison to svPPA, and svPPA performing significantly lower on the naming task in comparison to sbvFTD. These tasks predominantly correlated with grey matter (GM) volumes in the right and left ATL, respectively. Compared to HC, both svPPA and sbvFTD patients showed preserved performance on the perceptual face processing test (BFRT-S), and performance on the BFRT-S negatively correlated with GM volume in the right posterior superior temporal sulcus (pSTS).

Conclusion

Our results suggest that early in the disease, with the atrophy mostly restricted to the anterior temporal regions, SD patients do not present with perceptual deficits. However, more severe SD cases with atrophy in right posterior temporal regions might show lower performance on face perception tests, in addition to the semantic face processing deficits. Early sparing of face perceptual deficits in SD patients, regardless of hemispheric lateralization, furthers our understanding of clinical phenomenology and therapeutical approaches of this complex disease.

查看原文本刊更多论文

语义痴呆症患者人脸识别的感知和语义缺陷。

最新进展：语义痴呆（SD）患者，包括语义变异型原发性进行性失语症（svPPA）和语义行为变异型额颞叶痴呆（sbvFTD）患者，在识别面孔和已知人物方面表现出语义困难，这与右侧前颞叶（ATL）萎缩有关。然而，他们在人脸识别方面是否也存在感知障碍，目前仍不清楚：我们从加州大学旧金山分校记忆与衰老中心选取了 74 名 SD 患者（其中 54 名患有 svPPA 并以左侧 ATL 萎缩为主，20 名患有 sbvFTD 并以右侧 ATL 萎缩为主）和 36 名认知健康对照组（HC）。他们接受了感知面孔处理测试（Benton面部识别测试-简版；BFRT-S）和语义面孔处理测试（加州大学旧金山分校名人电池-识别、命名、语义联想-图片和文字子测试）以及结构性磁共振成像（MRI）。结果显示：svPPA 和 sbvFTD 患者在所有语义面孔处理测试中均表现受损，其中 sbvFTD 患者在名人面孔识别任务中的表现明显低于 svPPA，在命名任务中的表现明显低于 sbvFTD。这些任务分别与右侧和左侧ATL的灰质（GM）体积密切相关。与HC相比，svPPA和sbvFTD患者在知觉面孔加工测试（BFRT-S）中的表现均有所保留，且BFRT-S的表现与右侧后颞上沟（pSTS）的GM体积呈负相关：我们的研究结果表明，在疾病早期，由于萎缩主要局限于颞叶前部，SD 患者不会出现知觉障碍。然而，右侧后颞区萎缩的SD患者病情较重，除了会出现语义面孔处理障碍外，还可能在面孔感知测试中表现较差。无论大脑半球偏侧与否，SD 患者早期都不会出现面部知觉障碍，这进一步加深了我们对这种复杂疾病的临床现象和治疗方法的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychologia 医学-行为科学

CiteScore

5.10

自引率

3.80%

发文量

228

审稿时长

4 months

期刊介绍： Neuropsychologia is an international interdisciplinary journal devoted to experimental and theoretical contributions that advance understanding of human cognition and behavior from a neuroscience perspective. The journal will consider for publication studies that link brain function with cognitive processes, including attention and awareness, action and motor control, executive functions and cognitive control, memory, language, and emotion and social cognition.