Precious Cargo: The Role of Polymeric Nanoparticles in the Delivery of Covalent Drugs.

IF 4.2 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecules Pub Date : 2024-10-19 DOI:10.3390/molecules29204949

Daniel Weissberger, Martina H Stenzel, Luke Hunter

引用次数: 0

Abstract

Covalent drugs can offer significant advantages over non-covalent drugs in terms of pharmacodynamics (i.e., target-binding properties). However, the development of covalent drugs is sometimes hampered by pharmacokinetic limitations (e.g., low bioavailability, rapid metabolism and toxicity due to off-target binding). Polymeric nanoparticles offer a potential solution to these limitations. Delivering covalent drugs via polymeric nanoparticles provides myriad benefits in terms of drug solubility, permeability, lifetime, selectivity, controlled release and the opportunity for synergistic administration alongside other drugs. In this short review, we examine each of these benefits in turn, illustrated through multiple case studies.

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珍贵的货物：聚合物纳米颗粒在传递共价药物中的作用。

与非共价药物相比，共价药物在药效学（即目标结合特性）方面具有明显优势。然而，共价药物的开发有时会受到药代动力学的限制（如生物利用度低、代谢快以及由于脱靶结合而产生的毒性）。聚合物纳米粒子为解决这些限制提供了潜在的解决方案。通过聚合物纳米颗粒输送共价药物在药物溶解度、渗透性、寿命、选择性、控制释放以及与其他药物协同给药等方面具有诸多优势。在这篇简短的综述中，我们将通过多个案例研究逐一探讨这些优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecules 化学-有机化学

CiteScore

7.40

自引率

8.70%

发文量

7524

审稿时长

1.4 months

期刊介绍： Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.