Phenotyping in vivo chronic inflammation in multiple sclerosis by combined 11C-PBR28 MR-PET and 7T susceptibility-weighted imaging.

IF 4.8 2区 医学 Q1 CLINICAL NEUROLOGY
Constantina A Treaba, Elena Herranz, Valeria T Barletta, Ambica Mehndiratta, Jacob A Sloane, Tobias Granberg, Alessandro Miscioscia, Roberto Bomprezzi, Marco L Loggia, Caterina Mainero
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引用次数: 0

Abstract

Background: 11C-PBR28 positron emission tomography (PET), targeting the translocator protein, and paramagnetic rim lesions (PRL) have emerged as promising imaging markers of MS chronic inflammation. No consensus on which is the optimal marker exists.

Objectives: To investigate the ability of 11C-PBR28 PET and PRL assessment to identify chronic inflammation in white matter (WM) MS lesions and their relation to neurological impairment.

Methods: Based on 11C-PBR28 uptake, brain WM lesions from 30 MS patients were classified as PET active or inactive. The PRL presence was assessed on 7T phase reconstructions, T1/T2 ratio was calculated to measure WM microstructural integrity.

Results: Less than half (44%) of non-PRL WM lesions were active on 11C-PBR28 imaging either throughout the lesion (whole active) or at its periphery. PET peripherally active lesions and PRL did not differ in T1/T2 ratio and 11C-PBR28 uptake. A positive correlation was observed between PRL and active PET lesion count. Whole active PET lesion volume was the strongest predictor (β = 0.97, p < 0.001) of increased Expanded Disability Status Scale scores.

Conclusion: 11C-PBR28 imaging reveals more active WM lesions than 7T PRL assessment. Although PRL and PET active lesion counts are related, neurological disability is better explained by PET whole active lesion volume.

通过联合 11C-PBR28 MR-PET 和 7T 磁感加权成像对多发性硬化症体内慢性炎症进行表型分析。
背景:11C-PBR28正电子发射断层扫描(PET)和顺磁性边缘病变(PRL)已成为多发性硬化症慢性炎症的有前途的成像标记物。目前尚未就哪种标记物是最佳标记物达成共识:研究 11C-PBR28 PET 和 PRL 评估识别 MS 白质(WM)病变中慢性炎症的能力及其与神经功能损伤的关系:方法:根据11C-PBR28摄取情况,将30名多发性硬化症患者的脑白质病变分为PET活跃型和非活跃型。通过7T相位重建评估PRL的存在,计算T1/T2比值以衡量WM微结构的完整性:结果:不到一半(44%)的非PRL WM病变在11C-PBR28成像上是活跃的,无论是整个病变(整体活跃)还是病变周边。PET 周围活跃病灶和 PRL 在 T1/T2 比值和 11C-PBR28 摄取方面没有差异。PRL和PET活动病灶数之间呈正相关。结论:与 7T PRL 评估相比,11C-PBR28 成像可显示更多活跃的 WM 病灶。结论:11C-PBR28成像比7T PRL评估显示出更多的活动性WM病变。虽然PRL和PET活动性病变计数相关,但PET整个活动性病变体积能更好地解释神经系统残疾。
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来源期刊
Multiple Sclerosis Journal
Multiple Sclerosis Journal 医学-临床神经学
CiteScore
10.90
自引率
6.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585
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