David Garbers' Contributions to Chemotaxis Signaling in Sperm

IF 2.7 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Reproduction and Development Pub Date : 2024-10-24 DOI:10.1002/mrd.23774

U. B. Kaupp, Olivia Kendall

引用次数: 0

Abstract

This review focuses on the contribution of the late David Garbers to chemotaxis of sperm, in particular from sea urchin. We will describe his discovery of chemotactic peptides and their cognate receptors, his discovery of a sperm-specific, unique Na⁺/H⁺ exchanger that represents a chimera between a solute carrier (SLC) and an ion channel. Finally, we will discuss his contributions to the understanding of cAMP signaling in sperm via soluble adenylyl cyclase (sAC) and its control by Ca²⁺ ions.

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David Garbers 对精子趋化信号的贡献

这篇综述将重点介绍已故的大卫-加伯斯（David Garbers）对精子趋化（尤其是海胆精子）的贡献。我们将介绍他对趋化肽及其同源受体的发现，以及他对精子特异性、独特的 Na+/H+ 交换器的发现，该交换器是溶质载体（SLC）和离子通道的嵌合体。最后，我们将讨论他在理解精子中通过可溶性腺苷酸环化酶（sAC）发出的 cAMP 信号及其受 Ca2+ 离子控制方面的贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Reproduction and Development 生物-发育生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Molecular Reproduction and Development takes an integrated, systems-biology approach to understand the dynamic continuum of cellular, reproductive, and developmental processes. This journal fosters dialogue among diverse disciplines through primary research communications and educational forums, with the philosophy that fundamental findings within the life sciences result from a convergence of disciplines. Increasingly, readers of the Journal need to be informed of diverse, yet integrated, topics impinging on their areas of interest. This requires an expansion in thinking towards non-traditional, interdisciplinary experimental design and data analysis.