A brief guide to analyzing expression quantitative trait loci

IF 3.7 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecules and Cells Pub Date : 2024-11-01 DOI:10.1016/j.mocell.2024.100139

Byung Su Ko , Sung Bae Lee , Tae-Kyung Kim

引用次数: 0

Abstract

Molecular quantitative trait locus (molQTL) mapping has emerged as an important approach for elucidating the functional consequences of genetic variants and unraveling the causal mechanisms underlying diseases or complex traits. However, the variety of analysis tools and sophisticated methodologies available for molQTL studies can be overwhelming for researchers with limited computational expertise. Here, we provide a brief guideline with a curated list of methods and software tools for analyzing expression quantitative trait loci, the most widely studied type of molQTL.

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表达量性状位点分析简要指南。

分子量性状位点（molQTL）图谱已成为阐明遗传变异的功能性后果和揭示疾病或复杂性状的因果机制的重要方法。然而，对于计算能力有限的研究人员来说，用于 molQTL 研究的各种分析工具和复杂方法可能会让他们不知所措。在此，我们提供了一份简要指南，其中包括一份用于分析表达量性状位点（eQTL）的方法和软件工具的精选列表，eQTL是研究最为广泛的一种molQTL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecules and Cells 生物-生化与分子生物学

CiteScore

6.60

自引率

10.50%

发文量

审稿时长

2.3 months

期刊介绍： Molecules and Cells is an international on-line open-access journal devoted to the advancement and dissemination of fundamental knowledge in molecular and cellular biology. It was launched in 1990 and ISO abbreviation is "Mol. Cells". Reports on a broad range of topics of general interest to molecular and cell biologists are published. It is published on the last day of each month by the Korean Society for Molecular and Cellular Biology.