The Influence of Cholesterol on Membrane Targeted Bioactive Peptides: Modulating Peptide Activity Through Changes in Bilayer Biophysical Properties.

IF 3.3 4区工程技术 Q2 CHEMISTRY, PHYSICAL

Membranes Pub Date : 2024-10-17 DOI:10.3390/membranes14100220

Juan M Giraldo-Lorza, Chad Leidy, Marcela Manrique-Moreno

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Abstract

Cholesterol is a biological molecule that is essential for cellular life. It has unique features in terms of molecular structure and function, and plays an important role in determining the structure and properties of cell membranes. One of the most recognized functions of cholesterol is its ability to increase the level of lipid packing and rigidity of biological membranes while maintaining high levels of lateral mobility of the bulk lipids, which is necessary to sustain biochemical signaling events. There is increased interest in designing bioactive peptides that can act as effective antimicrobial agents without causing harm to human cells. For this reason, it becomes relevant to understand how cholesterol can affect the interaction between bioactive peptides and lipid membranes, in particular by modulating the peptides' ability to penetrate and disrupt the membranes through these changes in membrane rigidity. Here we discuss cholesterol and its role in modulating lipid bilayer properties and discuss recent evidence showing how cholesterol modulates bioactive peptides to different degrees.

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胆固醇对膜靶向生物活性肽的影响：胆固醇对膜靶向生物活性肽的影响：通过改变双分子层的生物物理特性调节肽的活性。

胆固醇是细胞生命不可或缺的生物分子。它在分子结构和功能方面具有独特的特征，在决定细胞膜的结构和特性方面发挥着重要作用。胆固醇最公认的功能之一是能够增加生物膜的脂质堆积和刚性，同时保持大量脂质的高水平横向流动性，这是维持生化信号事件所必需的。人们对设计生物活性肽的兴趣与日俱增，这种肽可以作为有效的抗菌剂，同时不会对人体细胞造成伤害。因此，了解胆固醇如何影响生物活性肽与脂质膜之间的相互作用，特别是通过膜刚性的变化调节肽穿透和破坏膜的能力，就变得非常重要。在此，我们将讨论胆固醇及其在调节脂质双分子层特性方面的作用，并讨论最近显示胆固醇如何在不同程度上调节生物活性肽的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Membranes Chemical Engineering-Filtration and Separation

CiteScore

6.10

自引率

16.70%

发文量

1071

审稿时长

11 weeks

期刊介绍： Membranes (ISSN 2077-0375) is an international, peer-reviewed open access journal of separation science and technology. It publishes reviews, research articles, communications and technical notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. Full experimental and/or methodical details must be provided.