[The dengue vaccine: a major scientific challenge and a public health issue].

IF 0.6 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

M S-medecine Sciences Pub Date : 2024-10-01 Epub Date: 2024-10-25 DOI:10.1051/medsci/2024116

Philippe Desprès, Dominique Salmon, Laurent Bellec, André Cabié, Marie-Lise Gougeon

引用次数: 0

Abstract

Almost half of the world's population is exposed to the risk of transmission of the four dengue virus serotypes (DENV 1-4), by mosquitoes of the genus Aedes. A dengue vaccine is effective if it induces prolonged protective immunity against all circulating viral strains, irrespective of the age and infection history of the vaccinated subject. An effective vaccine strategy against dengue is based on the injection of live attenuated viruses in a tetravalent formulation. In this review, we present the most promising candidate vaccines against dengue, their successes and also the questions raised by the correlates of protection that have been adopted to assess their level of effectiveness against the disease.

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[登革热疫苗：重大科学挑战和公共卫生问题]。

全球近一半的人口面临着四种登革热病毒血清型（DENV 1-4）通过伊蚊传播的风险。登革热疫苗如果能针对所有流行的病毒株诱导长期的保护性免疫，则是有效的，与接种对象的年龄和感染史无关。预防登革热的有效疫苗策略是注射四价减毒活疫苗。在这篇综述中，我们将介绍最有希望的登革热候选疫苗、它们的成功经验，以及为评估其对登革热的有效程度而采用的保护相关性所提出的问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

M S-medecine Sciences 医学-医学：研究与实验

CiteScore

0.80

自引率

14.30%

发文量

182

审稿时长

4-8 weeks

期刊介绍： m/s offers high-quality review articles in French, covering all areas of biomedical and health research, in a monthly magazine format (10 issues / year). m/s is read by the whole French-speaking community, in France but also in Belgium, Switzerland, Canada, Morocco, Algeria, Tunisia etc. m/s is not a primary publication, and thus will not consider unpublished data. Most articles are invited by the Editors, but spontaneous proposals are welcomed. Each issue combines news and views on the most recent scientific publications, as well as broadly accessible and updated review articles on a specific topic, and essays on science and society, history of science, public health, or reactions to published articles. Each year, m/s also publishes one or two thematic issues focused on a research topic of high interest. All review articles and essays are peer-reviewed.