Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and angina pectoris in US adults: a cross-sectional retrospective study based on NHANES 2009-2018.

IF 3.9 2区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Ying Cui, Mankyu Choi
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Abstract

Background: The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) plays a potential role in cardiovascular diseases. However, its association with angina pectoris remains unclear. Herein, we aimed to explore their relationship.

Methods: This cross-sectional retrospective study included the 2009-2018 data from 22,562 adults diagnosed with angina pectoris, retrieved from the National Health and Nutrition Examination Survey (NHANES) database. NHHR was estimated from laboratory data, and angina pectoris diagnosis was ascertained from the NHANES questionnaire.

Results: Angina pectoris risk was greater in the highest than in the lowest NHHR tertile (odds ratio [OR] = 1.61; 95% confidence interval (CI), 1.15-2.54; P = 0.006). Weighted logistic regression showed a positive association between NHHR and angina pectoris in the fully adjusted model (OR = 1.17; 95% CI, 1.07-1.28; P = 0.001). Restricted cubic spline analysis showed a linear association (P = 0.6572). Subgroup analyses indicated no significant differences across different stratifications (P > 0.05, all). Random forest analyses and Boruta algorithm corroborated that NHHR is a strong predictor of angina pectoris. Among the eight machine-learning models evaluated for predictive capabilities, the logistic regression model demonstrated the strongest predictive capability, with an area under the curve of 0.831.

Conclusions: Our study suggests that NHHR is a risk factor for angina pectoris and may be used for risk prediction and to inform future intervention programs to reduce its incidence.

美国成年人非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值 (NHHR) 与心绞痛之间的关系:基于 2009-2018 年 NHANES 的横断面回顾性研究。
背景:非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇的比率(NHHR)在心血管疾病中发挥着潜在作用。然而,其与心绞痛的关系仍不明确。在此,我们旨在探讨它们之间的关系:这项横断面回顾性研究纳入了从美国国家健康与营养调查(NHANES)数据库中获取的 22,562 名确诊为心绞痛的成人的 2009-2018 年数据。NHHR根据实验室数据估算,心绞痛诊断根据NHANES调查问卷确定:心绞痛风险在最高 NHHR 三分层中高于最低 NHHR 三分层(几率比 [OR] = 1.61;95% 置信区间 (CI),1.15-2.54;P = 0.006)。加权逻辑回归显示,在完全调整模型中,NHHR与心绞痛之间存在正相关(OR = 1.17;95% CI,1.07-1.28;P = 0.001)。限制性立方样条分析显示两者呈线性相关(P = 0.6572)。亚组分析表明,不同分层之间无显著差异(P > 0.05,全部)。随机森林分析和 Boruta 算法证实,NHHR 是预测心绞痛的有力指标。在评估预测能力的八个机器学习模型中,逻辑回归模型的预测能力最强,曲线下面积为 0.831:我们的研究表明,NHHR 是心绞痛的一个风险因素,可用于风险预测,并为未来降低心绞痛发病率的干预计划提供依据。
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来源期刊
Lipids in Health and Disease
Lipids in Health and Disease 生物-生化与分子生物学
CiteScore
7.70
自引率
2.20%
发文量
122
审稿时长
3-8 weeks
期刊介绍: Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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